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PEBP1 antibody (N-Term)

PEBP1 Reactivity: Mouse, Rat WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3032217
  • Target See all PEBP1 Antibodies
    PEBP1 (Phosphatidylethanolamine Binding Protein 1 (PEBP1))
    Binding Specificity
    • 11
    • 7
    • 7
    • 6
    • 6
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 74
    • 42
    • 22
    • 10
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Mouse, Rat
    Host
    • 69
    • 11
    • 2
    • 1
    Rabbit
    Clonality
    • 61
    • 18
    Polyclonal
    Conjugate
    • 50
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This PEBP1 antibody is un-conjugated
    Application
    • 64
    • 42
    • 30
    • 12
    • 9
    • 7
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    Antigen affinity
    Immunogen
    An amino acid sequence from the N-terminus of mouse PBP (QEVDEPPQHALRVDY) was used as the immunogen for this PBP antibody (100% rat homology).
    Isotype
    IgG
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    Discover our top product PEBP1 Primary Antibody
  • Application Notes
    The stated application concentrations are suggested starting amounts. Titration of the PBP antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL
    Restrictions
    For Research Use only
  • Buffer
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    Storage
    -20 °C
    Storage Comment
    After reconstitution, the PBP antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • Target
    PEBP1 (Phosphatidylethanolamine Binding Protein 1 (PEBP1))
    Alternative Name
    PBP (PEBP1 Products)
    Synonyms
    HCNP antibody, HCNPpp antibody, PBP antibody, PEBP antibody, PEBP-1 antibody, RKIP antibody, pbp antibody, hcnp antibody, pebp antibody, rkip antibody, Pbp antibody, Pbp1 antibody, Pbpr antibody, Rkip antibody, PEBP1 antibody, BcDNA:LP12095 antibody, CG18594 antibody, Dmel\\CG18594 antibody, T2 antibody, zgc:56033 antibody, zgc:76942 antibody, phosphatidylethanolamine binding protein 1 antibody, phosphatidylethanolamine binding protein 1 L homeolog antibody, phosphatidylethanolamine-binding protein antibody, phosphatidylethanolamine-binding protein,putative antibody, Phosphatidylethanolamine-binding protein 1 antibody, PEBP1 antibody, pebp1 antibody, Pebp1 antibody, pebp1.L antibody, RR_RS07785 antibody, PVX_235290 antibody, PVX_123630 antibody, PKH_143640 antibody, EAM_1207 antibody
    Background
    Phosphatidylethanolamine-binding protein inhibits the phosphorylation and activation of MEK by RAF1. PBP coimmunoprecipitates with RAF1 and MEK from cell lysates and colocalizes with RAF1 when examined by confocal microscopy. Overexpression interferes with the activation of MEK and ERK, induction of AP1-dependent reporter genes, and transformation elicited by an oncogenically activated RAF1 kinase. PBP expression was rapidly upregulated during induction of chemotherapy-triggered apoptosis in human prostate and breast cancer cell lines, and maximal expression correlated perfectly with the onset of apoptosis by Chatterjee et al(2004). Depletion of the protein decreased the mitotic index, the number of metaphase cells, traversal times from nuclear envelope breakdown to anaphase, and an override of mitotic checkpoints induced by spindle poisons.
    UniProt
    P70296
    Pathways
    Feeding Behaviour
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