HCN1 antibody (AA 618-890)

Catalog No. ABIN3042439

Product Details anti-HCN1 Antibody

Target: HCN1 (Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 1 (HCN1))

Binding Specificity: AA 618-890

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HCN1 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit IgG polyclonal antibody for Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(HCN1) detection. Tested with WB in Human,Mouse,Rat.

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(HCN1) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: hyperpolarization activated cyclic nucleotide-gated potassium channel 1
Protein Name: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human HCN1 recombinant protein (Position: E618-L890). Human HCN1 shares 82% amino acid (aa) sequence identity with both mouse and rat HCN1.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat, The detection limit for HCN1 is approximately 0.25 ng/lane under reducing conditions.
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Target Details for HCN1

Target: HCN1 (Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 1 (HCN1))

Alternative Name: HCN1 (HCN1 Products)

Synonyms: BCNG-1 antibody, BCNG1 antibody, HAC-2 antibody, Bcng1 antibody, C630013B14Rik antibody, HAC2 antibody, hyperpolarization activated cyclic nucleotide gated potassium channel 1 antibody, hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 antibody, hyperpolarization-activated, cyclic nucleotide-gated K+ 1 antibody, hcn1 antibody, HCN1 antibody, Hcn1 antibody

Background: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, also known as HAC-2 or BCNG-1, is a protein that in humans is encoded by the HCN1 gene. It is mapped to 5p12. The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. It may mediates responses to sour stimuli.

Synonyms: BCNG-1 antibody|BCNG1 antibody|Brain cyclic nucleotide gated channel 1 antibody|Brain cyclic nucleotide-gated channel 1 antibody|HAC 2 antibody|HAC2 antibody|HCN1 antibody|HCN1_HUMAN antibody|Hyperpolarization activated cyclic nucleotide gated potassium channel 1 antibody|Potassium channel, voltage-gated, brain, 1 antibody|Potassium/sodium hyperpolarization activated cyclic nucleotide gated channel 1 antibody|Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 antibody

Gene ID: 348980

UniProt: O60741

Pathways: Asymmetric Protein Localization