GBP1 antibody (C-Term)

Catalog No. ABIN3042677

Product Details anti-GBP1 Antibody

Target: GBP1 (Guanylate Binding Protein 1, Interferon-Inducible (GBP1))

Binding Specificity: AA 566-589, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GBP1 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit IgG polyclonal antibody for Guanylate-binding protein 1(GBP1) detection. Tested with WB in Human.

Sequence: QKESRIMKNE IQDLQTKMRR RKAC

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Guanylate-binding protein 1(GBP1) detection. Tested with WB in Human.
Gene Name: guanylate binding protein 1, interferon-inducible
Protein Name: Guanylate-binding protein 1

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human GBP1(566-589aa QKESRIMKNEIQDLQTKMRRRKAC).

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Thimerosal (Merthiolate), Sodium azide

Precaution of Use: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for GBP1

Target: GBP1 (Guanylate Binding Protein 1, Interferon-Inducible (GBP1))

Alternative Name: GBP1 (GBP1 Products)

Synonyms: guanylate binding protein 1 antibody, guanylate binding protein 1, interferon-inducible antibody, guanylate binding protein 1, interferon-inducible, 67kD antibody, GBP1 antibody, Gbp1 antibody, gbp1 antibody

Background: Interferons induce a large number of genes in their target cells, including those coding for guanylate-binding proteins(GBPs). GBPs, such as GBP1, are characterized by their ability to specifically bind guanine nucleotides(GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. The 593-amino acid GBP1 protein shares 77 % and 88 % identity with GBP2 and GBP3, respectively. All GBPs, including GBP1, have a conserved N-terminal globular GTP-binding domain containing 2 consensus sequences and a third T(L/V)RD sequence not found in other GTPases. The GBP1 gene to the GBP gene cluster on chromosome 1p22.2. It is located telomeric to GBP2 and centromeric to GBP3. High expression of GBP1, GBP2, and GBP3 are in endothelial cells after stimulation with IFNG, TNF, or IL1B .

Synonyms: GBP 1 antibody|GBP-1 antibody|GBP1 antibody|GBP1_HUMAN antibody|GTP binding protein 1 antibody|GTP-binding protein 1 antibody|Guanine nucleotide binding protein 1 antibody|Guanine nucleotide-binding protein 1 antibody|Guanylate binding protein 1 antibody|Guanylate binding protein 1 interferon inducible 67 kDa antibody|Guanylate binding protein 1 interferon inducible antibody|HuGBP 1 antibody|HuGBP-1 antibody|HuGBP1 antibody|Interferon induced guanylate binding protein 1 antibody|Interferon-induced guanylate-binding protein 1 antibody|OTTHUMP00000012352 antibody

UniProt: P32455

Pathways: Cellular Response to Molecule of Bacterial Origin