IRF8 antibody (C-Term)

Catalog No. ABIN3042833

Product Details anti-IRF8 Antibody

Target: IRF8 (Interferon Regulatory Factor 8 (IRF8))

Binding Specificity: AA 411-426, C-Term

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRF8 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit IgG polyclonal antibody for Interferon regulatory factor 8(IRF8) detection. Tested with WB in Human,Mouse,Rat.

Sequence: ASHQRSFFRE NQQITV

Cross-Reactivity (Details): Predicted Cross Reactivity: mouse
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Characteristics: Rabbit IgG polyclonal antibody for Interferon regulatory factor 8(IRF8) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: interferon regulatory factor 8
Protein Name: Interferon regulatory factor 8

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human IRF8(411-426aa ASHQRSFFRENQQITV), different from the related mouse and rat sequences by two amino acids.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Thimerosal (Merthiolate), Sodium azide

Precaution of Use: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for IRF8

Target: IRF8 (Interferon Regulatory Factor 8 (IRF8))

Alternative Name: IRF8 (IRF8 Products)

Synonyms: zgc:92252 antibody, IRF8 antibody, MGC140338 antibody, DKFZp469B0320 antibody, H-ICSBP antibody, ICSBP antibody, ICSBP1 antibody, IRF-8 antibody, icsbp1 antibody, AI893568 antibody, Icsbp1 antibody, Myls antibody, interferon regulatory factor 8 antibody, interferon regulatory factor 8 L homeolog antibody, irf8 antibody, IRF8 antibody, irf8.L antibody, Irf8 antibody

Background: Interferon regulatory factor 8(IRF8) also known as Interferon consensus sequence-binding protein(ICSBP), is a protein that in humans is encoded by the IRF8 gene. By genomic sequence analysis, the IRF8 gene is mapped to chromosome 16q24.1. Interferon consensus sequence-binding protein(ICSBP) is a transcription factor of the interferon(IFN) regulatory factor(IRF) family. The IRF family proteins bind to the IFN-stimulated response element(ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. IRF8 is a transcription factor that plays critical roles in the regulation of lineage commitment and in myeloid cell maturation including the decision for a common myeloid progenitor(CMP) to differentiate into a monocyte precursor cell.

Synonyms: H ICSBP antibody|H-ICSBP antibody|HGNC:5358 antibody|HGNC5358 antibody|HICSBP antibody|ICSBP 1 antibody|ICSBP antibody|ICSBP1 antibody|Interferon Consensus Sequence Binding Protein 1 antibody|Interferon consensus sequence binding protein antibody|Interferon consensus sequence-binding protein antibody|Interferon Regulatory Factor 8 antibody|IRF 8 antibody|IRF-8 antibody|IRF8 antibody|IRF8_HUMAN antibody|MYLS antibody

UniProt: Q02556

Pathways: Cellular Response to Molecule of Bacterial Origin