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PCSK9 antibody (C-Term)

PCSK9 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3042887
  • Target See all PCSK9 Antibodies
    PCSK9 (Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))
    Binding Specificity
    • 15
    • 7
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 671-687, C-Term
    Reactivity
    • 61
    • 23
    • 23
    Human
    Host
    • 59
    • 4
    • 3
    • 1
    Rabbit
    Clonality
    • 58
    • 8
    • 1
    Polyclonal
    Conjugate
    • 38
    • 7
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PCSK9 antibody is un-conjugated
    Application
    • 58
    • 27
    • 22
    • 13
    • 13
    • 13
    • 12
    • 7
    • 7
    • 5
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purpose
    Rabbit IgG polyclonal antibody for Proprotein convertase subtilisin/kexin type 9(PCSK9) detection. Tested with WB, IHC-P in Human.
    Sequence
    AVTAVAICCR SRHLAQA
    Cross-Reactivity (Details)
    No cross reactivity with other proteins.
    Characteristics
    Rabbit IgG polyclonal antibody for Proprotein convertase subtilisin/kexin type 9(PCSK9) detection. Tested with WB, IHC-P in Human.
    Gene Name: proprotein convertase subtilisin/kexin type 9
    Protein Name: Proprotein convertase subtilisin/kexin type 9
    Purification
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence at the C-terminus of human PCSK9(671-687aa AVTAVAICCRSRHLAQA).
    Isotype
    IgG
    Top Product
    Discover our top product PCSK9 Primary Antibody
  • Application Notes
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Comment

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Preservative
    Thimerosal (Merthiolate), Sodium azide
    Precaution of Use
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
    Expiry Date
    12 months
  • Target
    PCSK9 (Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))
    Alternative Name
    PCSK9 (PCSK9 Products)
    Synonyms
    FH3 antibody, HCHOLA3 antibody, LDLCQ1 antibody, NARC-1 antibody, NARC1 antibody, PC9 antibody, AI415265 antibody, AI747682 antibody, Narc1 antibody, proprotein convertase subtilisin/kexin type 9 antibody, proprotein convertase subtilisin/kexin type 9 L homeolog antibody, PCSK9 antibody, pcsk9.L antibody, pcsk9 antibody, Pcsk9 antibody
    Background
    Proprotein convertase subtilisin/kexin type 9, also known as PCSK9, is an enzyme that in humans is encoded by the PCSK9 gene. This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. By genomic sequence analysis, PCSK9 was mapped to chromosome 1p32. This gene is a crucial player in the regulation of plasma cholesterol homeostasis. It may prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. PCSK9 can induce ubiquitination of LDLR leading to its subsequent degradation. This gene is involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway.

    Synonyms: Convertase subtilisin/kexin type 9 preproprotein antibody|FH3 antibody|HCHOLA3 antibody|Hypercholesterolemia autosomal dominant 3 antibody|LDLCQ1 antibody|NARC 1 antibody|NARC-1 antibody|NARC1 antibody|Neural apoptosis regulated convertase 1 antibody|Neural apoptosis-regulated convertase 1 antibody|PC 9 antibody|PC9 antibody|PCSK 9 antibody|PCSK9 antibody|PCSK9_HUMAN antibody|Proprotein convertase 9 antibody|Proprotein convertase PC9 antibody|Proprotein convertase subtilisin/kexin type 9 antibody|PSEC0052 antibody|Subtilisin/kexin like protease PC9 antibody|Subtilisin/kexin-like protease PC9 antibody
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