CXCR2 antibody (Middle Region)
-
- Target See all CXCR2 Antibodies
- CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))
-
Binding Specificity
- AA 196-212, Middle Region
-
Reactivity
- Human, Mouse, Rat
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This CXCR2 antibody is un-conjugated
-
Application
- Western Blotting (WB)
- Purpose
- Rabbit IgG polyclonal antibody for C-X-C chemokine receptor type 2(CXCR2) detection. Tested with WB in Human,Mouse,Rat.
- Sequence
- CYEDMGNNTA NWRMLLR
- Cross-Reactivity (Details)
- No cross reactivity with other proteins.
- Characteristics
-
Rabbit IgG polyclonal antibody for C-X-C chemokine receptor type 2(CXCR2) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: chemokine(C-X-C motif) receptor 2
Protein Name: C-X-C chemokine receptor type 2(CXC-R2/CXCR-2) - Purification
- Immunogen affinity purified.
- Immunogen
- A synthetic peptide corresponding to a sequence in the middle region of human CXCR2(196-212aa CYEDMGNNTANWRMLLR), different from the related mouse sequence by six amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product CXCR2 Primary Antibody
-
-
- Application Notes
-
WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users. - Comment
-
Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- Concentration
- 500 μg/mL
- Buffer
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
- Preservative
- Thimerosal (Merthiolate), Sodium azide
- Precaution of Use
- This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
-
At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
-
-
Overexpression of GRK6 attenuates neuropathic pain via suppression of CXCR2 in rat dorsal root ganglion." in: Molecular pain, Vol. 12, (2016) (PubMed).
: "NF?B-mediated CXCL1 production in spinal cord astrocytes contributes to the maintenance of bone cancer pain in mice." in: Journal of neuroinflammation, Vol. 11, pp. 38, (2014) (PubMed).
: "Chemokine CXCL1 enhances inflammatory pain and increases NMDA receptor activity and COX-2 expression in spinal cord neurons via activation of CXCR2." in: Experimental neurology, Vol. 261, pp. 328-36, (2014) (PubMed).
: "Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice." in: Brain : a journal of neurology, Vol. 137, Issue Pt 8, pp. 2193-209, (2014) (PubMed).
: "Chemokine contribution to neuropathic pain: respective induction of CXCL1 and CXCR2 in spinal cord astrocytes and neurons." in: Pain, Vol. 154, Issue 10, pp. 2185-97, (2013) (PubMed).
: "
-
Overexpression of GRK6 attenuates neuropathic pain via suppression of CXCR2 in rat dorsal root ganglion." in: Molecular pain, Vol. 12, (2016) (PubMed).
-
- Target
- CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))
- Alternative Name
- CXCR2 (CXCR2 Products)
- Synonyms
- CD182 antibody, CDw128b antibody, CMKAR2 antibody, IL8R2 antibody, IL8RA antibody, IL8RB antibody, CXC-R2 antibody, CXCR-2 antibody, CD128 antibody, CDw128 antibody, Cmkar2 antibody, Gpcr16 antibody, IL-8Rh antibody, IL-8rb antibody, Il8rb antibody, mIL-8RH antibody, C-X-C motif chemokine receptor 2 antibody, chemokine (C-X-C motif) receptor 2 antibody, Cxcr2 antibody, CXCR2 antibody
- Background
-
CXCR2 is a receptor for Interleukin 8, which is a powerful neutrophil chemotactic factor. It is a member of the GPCR family(subfamily, chemokine). Binding of IL8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL8 with a high affinity and to GRO/MGSA and NAP2 also with a high affinity. It has been reported to be expressed in a wide variety of tissues. ESTs have been isolated from human placenta and thymus libraries.
Synonyms: C-X-C chemokine receptor type 2 antibody|CD 182 antibody|CD182 antibody|CD182 antigen antibody|CDw128b antibody|Chemokine(CXC) receptor 2 antibody|CMKAR2 antibody|CXC-R2 antibody|CXCR 2 antibody|CXCR-2 antibody|CXCR2 antibody|CXCR2_HUMAN antibody|GRO/MGSA receptor antibody|High affinity interleukin-8 receptor B antibody|IL 8 receptor type 2 antibody|IL 8R B antibody|IL-8 receptor type 2 antibody|IL-8R B antibody|IL8 RB antibody|IL8 receptor type 2 antibody|IL8R B antibody|IL8R2 antibody|IL8RA antibody|Interleukin 8 Receptor B antibody - UniProt
- P25025
- Pathways
- cAMP Metabolic Process
-