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MAP3K2 antibody (C-Term)

MAP3K2 Reactivity: Human, Rat WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3043184
  • Target See all MAP3K2 Antibodies
    MAP3K2 (Mitogen-Activated Protein Kinase Kinase Kinase 2 (MAP3K2))
    Binding Specificity
    • 8
    • 8
    • 7
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 606-619, C-Term
    Reactivity
    • 50
    • 29
    • 14
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Rat
    Host
    • 48
    • 3
    Rabbit
    Clonality
    • 38
    • 13
    Polyclonal
    Conjugate
    • 24
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This MAP3K2 antibody is un-conjugated
    Application
    • 33
    • 21
    • 16
    • 6
    • 4
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB)
    Purpose
    Rabbit IgG polyclonal antibody for Mitogen-activated protein kinase kinase kinase 2(MAP3K2) detection. Tested with WB in Human,Mouse,Rat.
    Sequence
    SADELLRHMF VHYH
    Cross-Reactivity (Details)
    Predicted Cross Reactivity: mouse
    No cross reactivity with other proteins.
    Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.
    Characteristics
    Rabbit IgG polyclonal antibody for Mitogen-activated protein kinase kinase kinase 2(MAP3K2) detection. Tested with WB in Human,Mouse,Rat.
    Gene Name: mitogen-activated protein kinase kinase kinase 2
    Protein Name: Mitogen-activated protein kinase kinase kinase 2
    Purification
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence at the C-terminus of human MEKK2(606-619aa SADELLRHMFVHYH), different from the related rat and mouse sequences by one amino acid.
    Isotype
    IgG
    Top Product
    Discover our top product MAP3K2 Primary Antibody
  • Application Notes
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
    Other applications have not been tested. Optimal dilutions should be determined by end users.
    Comment

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Preservative
    Thimerosal (Merthiolate), Sodium azide
    Precaution of Use
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
    Expiry Date
    12 months
  • Li, Zhang, Zhou, Li, Liu, Wang, Bai, Zhao, Shi, Zhang, Ye: "The oncoprotein HBXIP enhances migration of breast cancer cells through increasing filopodia formation involving MEKK2/ERK1/2/Capn4 signaling." in: Cancer letters, Vol. 355, Issue 2, pp. 288-96, (2014) (PubMed).

  • Target
    MAP3K2 (Mitogen-Activated Protein Kinase Kinase Kinase 2 (MAP3K2))
    Alternative Name
    MAP3K2 (MAP3K2 Products)
    Synonyms
    Mekk2 antibody, MEKK2 antibody, MEKK2B antibody, 9630061B06Rik antibody, AI585793 antibody, Mekk2b antibody, mitogen activated protein kinase kinase kinase 2 antibody, mitogen-activated protein kinase kinase kinase 2 antibody, Map3k2 antibody, MAP3K2 antibody
    Background
    MAP3K2, mitogen-activated protein kinase kinase kinase 2, also known as MEKK2, belongs to the mitogen-activated protein kinase(MAPK) kinase kinase gene family, which is involved in regulating multiple MAPK signaling pathways. Endogenous MAP3K2 localized mainly to the cytosol of unstimulated HeLa cells and rat fibroblasts. The MAP3K2 gene is mapped to chromosome 2 by the International Radiation Hybrid Mapping Consortium. MAP3K2 is a major upstream activator of the JNK, MAPK cascade. MAP3K2 was identifies as 1 of 6 kinases that regulate different steps of the caveolar cycle. Silencing of MAP3K2 strongly reduced kiss-and-run dynamics, leading to an accumulation of caveolar structures at the cell surface without affecting caveolae coat assembly or clustering.

    Synonyms: M3K2_HUMAN antibody|Map3k2 antibody|MAPK/ERK kinase kinase 2 antibody|MEK kinase 2 antibody|MEKK 2 antibody|MEKK2b antibody|Mitogen activated protein kinase kinase kinase 2 antibody|Mitogen-activated protein kinase kinase kinase 2 antibody
    UniProt
    Q9Y2U5
    Pathways
    MAPK Signaling
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