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ITCH antibody (Middle Region)

ITCH Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3043253
  • Target See all ITCH Antibodies
    ITCH (Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH))
    Binding Specificity
    • 10
    • 8
    • 7
    • 6
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 410-437, Middle Region
    Reactivity
    • 37
    • 34
    • 8
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 45
    • 3
    • 1
    Rabbit
    Clonality
    • 45
    • 4
    Polyclonal
    Conjugate
    • 27
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ITCH antibody is un-conjugated
    Application
    • 34
    • 33
    • 7
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB)
    Purpose
    Rabbit IgG polyclonal antibody for E3 ubiquitin-protein ligase Itchy homolog(ITCH) detection. Tested with WB in Human.
    Sequence
    AMQQFNQRFI YGNQDLFATS QSKEFDPL
    Cross-Reactivity (Details)
    No cross reactivity with other proteins.
    Characteristics
    Rabbit IgG polyclonal antibody for E3 ubiquitin-protein ligase Itchy homolog(ITCH) detection. Tested with WB in Human.
    Gene Name: itchy E3 ubiquitin protein ligase
    Protein Name: E3 ubiquitin-protein ligase Itchy homolog
    Purification
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence in the middle region of human ITCH/AIP4 (410-437aa AMQQFNQRFIYGNQDLFATSQSKEFDPL), different from the related mouse sequence by one amino acid.
    Isotype
    IgG
    Top Product
    Discover our top product ITCH Primary Antibody
  • Application Notes
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
    Notes: Tested Species: Species with positive results.
    Other applications have not been tested. Optimal dilutions should be determined by end users.
    Comment

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Target
    ITCH (Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH))
    Alternative Name
    ITCH (ITCH Products)
    Synonyms
    AIF4 antibody, AIP4 antibody, NAPP1 antibody, dJ468O1.1 antibody, 6720481N21Rik antibody, 8030492O04Rik antibody, A130065M08 antibody, C230047C07Rik antibody, itchy E3 ubiquitin protein ligase antibody, itchy, E3 ubiquitin protein ligase antibody, ITCH antibody, Itch antibody
    Background
    ITCH is an ubiquitin-conjugating enzyme. This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

    Synonyms: AIF4 antibody|AIP4 antibody|Atrophin 1 interacting protein 4 antibody|Atrophin-1-interacting protein 4 antibody|dJ468O1.1 antibody|dJ468O1.1 (atrophin 1 interacting protein 4 (AIP4)) antibody|dJ468O1.1 atrophin 1 interacting protein 4 AIP4 antibody|E3 ubiquitin protein ligase Itchy homolog antibody|E3 ubiquitin-protein ligase Itchy homolog antibody|EC 6.3.2 antibody|Itch antibody|ITCH_HUMAN antibody|Itchy E3 ubiquitin protein ligase antibody|Itchy E3 ubiquitin protein ligase homolog antibody|Itchy E3 ubiquitin protein ligase homolog mouse antibody|Itchy E3 ubiquitin protein ligase, mouse, homolog of antibody|itchy homolog E3 ubiquitin protein ligase antibody|Itchy mouse homolog E3 ubiquitin protein ligase antibody|NAPP1 antibody|NFE2 associated polypeptide 1 antibody| NFE2-associated polypeptide 1 antibody|Ubiquitin protein ligase ITCH antibody
    Gene ID
    83737
    UniProt
    Q96J02
    Pathways
    Activation of Innate immune Response, CXCR4-mediated Signaling Events
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