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NR3C2 antibody (C-Term)

NR3C2 Reactivity: Human, Rat, Mouse WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3043575
  • Target See all NR3C2 Antibodies
    NR3C2 (Nuclear Receptor Subfamily 3, Group C, Member 2 (NR3C2))
    Binding Specificity
    • 16
    • 15
    • 15
    • 7
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 950-984, C-Term
    Reactivity
    • 57
    • 45
    • 29
    • 17
    • 7
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    Human, Rat, Mouse
    Host
    • 70
    • 5
    Rabbit
    Clonality
    • 69
    • 6
    Polyclonal
    Conjugate
    • 27
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    This NR3C2 antibody is un-conjugated
    Application
    • 72
    • 39
    • 39
    • 20
    • 14
    • 12
    • 10
    • 9
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB)
    Purpose
    Rabbit IgG polyclonal antibody for Mineralocorticoid receptor(NR3C2) detection. Tested with WB in Human,Mouse,Rat.
    Sequence
    HALKVEFPAM LVEIISDQLP KVESGNAKPL YFHRK
    Cross-Reactivity (Details)
    No cross reactivity with other proteins.
    Characteristics
    Rabbit IgG polyclonal antibody for Mineralocorticoid receptor(NR3C2) detection. Tested with WB in Human,Mouse,Rat.
    Gene Name: nuclear receptor subfamily 3, group C, member 2
    Protein Name: Mineralocorticoid receptor
    Purification
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence at the C-terminus of human NR3C2 (950-984aa HALKVEFPAMLVEIISDQLPKVESGNAKPLYFHRK), different from the related mouse sequence by one amino acid, and from the related rat sequence by two amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product NR3C2 Primary Antibody
  • Application Notes
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
    Notes: Tested Species: Species with positive results.
    Other applications have not been tested. Optimal dilutions should be determined by end users.
    Comment

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Rigiracciolo, Scarpelli, Lappano, Pisano, Santolla, Avino, De Marco, Bussolati, Maggiolini, De Francesco: "GPER is involved in the stimulatory effects of aldosterone in breast cancer cells and breast tumor-derived endothelial cells." in: Oncotarget, Vol. 7, Issue 1, pp. 94-111, (2016) (PubMed).

  • Target
    NR3C2 (Nuclear Receptor Subfamily 3, Group C, Member 2 (NR3C2))
    Alternative Name
    NR3C2 (NR3C2 Products)
    Synonyms
    mr antibody, si:ch211-189l17.1 antibody, LOC100302443 antibody, NR3C2 antibody, LOC443144 antibody, MLR antibody, MR antibody, MCR antibody, NR3C2VIT antibody, Mlr antibody, mlr antibody, nuclear receptor subfamily 3, group C, member 2 antibody, nuclear receptor subfamily 3 group C member 2 antibody, mineralocorticoid receptor antibody, nuclear receptor subfamily 3 group C member 2 L homeolog antibody, nr3c2 antibody, NR3C2 antibody, LOC443144 antibody, Nr3c2 antibody, nr3c2.L antibody
    Background
    NR3C2 (nuclear receptor subfamily 3, group C, member 2), also known as MR (mineralocorticoid receptor), is a protein that in humans is encoded by the NR3C2 gene that is located on chromosome 4q31.1-31.2. It belongs to the nuclear receptor family where the ligand diffuses into cells, interacts with the receptor and results in a signal transduction affecting specific gene expression in the nucleus. This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants.

    Synonyms: Aldosterone receptor antibody|MCR antibody|MCR_HUMAN antibody|MGC133092 antibody| Mineralocorticoid receptor antibody|MLR antibody|MR antibody|NR3 C2 antibody|NR3C2 antibody|NR3C2 protein antibody|Nuclear receptor subfamily 3 group C member 2 antibody
    Gene ID
    4306
    UniProt
    P08235
    Pathways
    ACE Inhibitor Pathway, Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway
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