Insulin antibody (INS)

Details for Product anti-INS Antibody No. ABIN3043651, Supplier: Log in to see
Antigen
  • ins1
  • xins
  • ins1-a
  • Insulin
  • IDDM2
  • ILPR
  • IRDN
  • MODY10
  • AA986540
  • Ins-2
  • InsII
  • Mody
  • Mody4
  • proinsulin
  • zgc:109842
  • insulin
  • insulin precursor
  • insulin II
  • preproinsulin
  • ins
  • PIN
  • INS
  • Ins
  • INS-IGF2
  • Ins2
Alternatives
anti-Human Insulin antibody for Immunohistochemistry (Paraffin-embedded Sections)
Reactivity
Human, Rabbit, Rat (Rattus)
718
278
252
231
185
107
10
8
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7
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5
3
3
2
2
2
2
2
1
1
1
1
1
1
1
Host
Mouse
540
210
50
9
4
2
1
Clonality (Clone)
Monoclonal ()
Conjugate
This Insulin antibody is un-conjugated
38
29
27
15
14
13
7
7
7
7
7
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
2
2
2
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
334
231
192
169
168
143
107
66
57
33
32
32
23
23
21
7
5
4
4
4
3
2
2
2
1
1
1
1
1
1
1
Options
Supplier
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Supplier Product No.
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Purpose Mouse IgG monoclonal antibody for Insulin, insulin (INS) detection. Tested with IHC-P in Human,rabbit,rat. No cross reactivity with other proteins.
Immunogen Human insulin.
Clone K36AC10
Isotype IgG1
Cross-Reactivity (Details) No cross reactivity with other proteins.
Characteristics Mouse IgG monoclonal antibody for Insulin, insulin (INS) detection. Tested with IHC-P in Human,rabbit,rat.
Gene Name: insulin
Protein Name: Insulin
Purification Ascites
Plasmids, Primers & others Plasmids, Primers & others Insulin products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name INS (INS Antibody Abstract)
Background Insulin, synthesized by the beta cells of the islets of Langerhans, consists of 2 dissimilar polypeptide chains, A and B, which are linked by 2 disulfide bonds. The insulin gene contains 3 exons and 2 introns, exon 2 encodes the signal peptide, the B chain, and part of the C peptide, while exon 3 encodes the remainder of the C peptide and the A chain. Localization of the human insulin gene to the distal end of the short arm of chromosome 11. Harper et al.(1981) and Harper and Saunders(1981) assigned the insulin gene to 11p15.5 by in situ hybridization.

Synonyms: PROINSULIN|ILPR|IRDN|IDDM2|MODY10|Insulin2|Ins-2
Gene ID 3630, 16334, 24509
UniProt P01308, P01326, P01323
Pathways NF-kappaB Signaling, RTK Signaling, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Hormone Activity, Carbohydrate Homeostasis, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Autophagy, Negative Regulation of intrinsic apoptotic Signaling, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation
Application Notes IHC-P: Concentration: 0.4-1 μg/mL, Species: Human, rabbit, rat
Notes: Other applications have not been tested. Optimal dilutions should be determined by end users.
Comment

Antibody can be supported by ABIN921230 in IHC(P).

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 1 mL of PBS buffer will yield a concentration of 100 μg/mL.
Concentration 100 μg/mL
Buffer Mouse ascites fluid, 1.2 % sodium acetate, 2 mg BSA, with 0.01 mg Sodium azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
Supplier Images
Immunohistochemistry (IHC) image for anti-Insulin (INS) antibody (ABIN3043651) Anti-Insulin antibody (monoclonal), IHC(P) IHC(P): Rat Pancreas Tissue
Immunohistochemistry (IHC) image for anti-Insulin (INS) antibody (ABIN3043651) Anti-Insulin antibody (monoclonal), IHC(P) IHC(P): Rat Pancreas Tissue
Product cited in: Liu, Raynal, Bailbé, Gausseres, Carbonne, Autier, Movassat, Kergoat, Portha: "Expression of the kynurenine pathway enzymes in the pancreatic islet cells. Activation by cytokines and glucolipotoxicity." in: Biochimica et biophysica acta, Vol. 1852, Issue 5, pp. 980-91, 2015 (PubMed).

Liu, Gu, Zhao, An, Yang: "Glypican 4 may be involved in the adipose tissue redistribution in high-fat feeding C57BL/6J mice with peroxisome proliferators-activated receptor ? agonist rosiglitazone treatment." in: Experimental and therapeutic medicine, Vol. 8, Issue 6, pp. 1813-1818, 2014 (PubMed).

Xu, Dong, Huang, Li, Qin, Ren, Guo, Chen, Huang: "Decreased osteoclastogenesis, osteoblastogenesis and low bone mass in a mouse model of type 2 diabetes." in: Molecular medicine reports, Vol. 10, Issue 4, pp. 1935-41, 2014 (PubMed).

Adise, Saliu, Maldonado, Khatri, Cardoso, Rodríguez-Contreras: "Effect of maternal care on hearing onset induced by developmental changes in the auditory periphery." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 13, pp. 4528-33, 2014 (PubMed).

Ding, Zhu, Yin, Liu, Zhang, Bernier, Zhao: "Pyrrolidine dithiocarbamate protects pancreatic ?-cells from oxidative damage through regulation of FoxO1 activity in type 2 diabetes rats." in: Acta biochimica et biophysica Sinica, Vol. 46, Issue 7, pp. 582-9, 2014 (PubMed).

Chen, Yang, He, Song, Liu: "Effect of sericin on diabetic hippocampal growth hormone/insulin-like growth factor 1 axis." in: Neural regeneration research, Vol. 8, Issue 19, pp. 1756-64, 2014 (PubMed).

Zhang, Ye, Wang, Gao, Tan, Zhuo, Liu, Xia, Yang, Li: "Kidney-targeted transplantation of mesenchymal stem cells by ultrasound-targeted microbubble destruction promotes kidney repair in diabetic nephropathy rats." in: BioMed research international, Vol. 2013, pp. 526367, 2013 (PubMed).

Zhou, Zhou, Zeng: "Experimental diabetes treated with trigonelline: effect on ? cell and pancreatic oxidative parameters." in: Fundamental & clinical pharmacology, Vol. 27, Issue 3, pp. 279-87, 2013 (PubMed).

Hu, Yuan, Li, Huang, Mao, Zhang, Lin, Sun, Zhong, Tang, Lu: "Anti-Diabetic Activities of Jiaotaiwan in db/db Mice by Augmentation of AMPK Protein Activity and Upregulation of GLUT4 Expression." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2013, pp. 180721, 2013 (PubMed).

Gao, Liu, Liu, Chen, Li, Lei, Sun, Li, Liu, Shen: "A refined-JinQi-JiangTang tablet ameliorates prediabetes by reducing insulin resistance and improving beta cell function in mice." in: Journal of ethnopharmacology, Vol. 151, Issue 1, pp. 675-85, 2013 (PubMed).

Wang, Ni, Xu, Liang, Du, Gu: "Effects of long-term high-fat/high-energy and high-protein diets on insulin and ghrelin expression in developing rats." in: Endocrine research, Vol. 37, Issue 3, pp. 97-109, 2012 (PubMed).

Jiang, Deng, Duan, Chen, Xiang, Lu, Ma: "Somatostatin receptors SSTR2 and SSTR5 are expressed in the human thoracic duct." in: Lymphology, Vol. 44, Issue 1, pp. 21-8, 2011 (PubMed).

Su, Meng, Sun, Liu, Su: "Intramuscular injection of soluble receptor for advanced glycation endproducts expression vector prevents the development of streptozotocin-induced diabetes mellitus in rats on high fat diet." in: Journal of diabetes, Vol. 3, Issue 4, pp. 309-16, 2011 (PubMed).

Xu, Ke, Liang, Wang, Pei, Du: "PEG-rhGH therapy for small for gestational age rats and effects on their metabolic parameters." in: Hormone research in pædiatrics, Vol. 76, Issue 1, pp. 35-43, 2011 (PubMed).

Zhang, Jin, Hu, Yu, Li, Ding, Kang, Wang: "Protective response against type 1 diabetes in nonobese diabetic mice after coimmunization with insulin and DNA encoding proinsulin." in: Human gene therapy, Vol. 21, Issue 2, pp. 171-8, 2010 (PubMed).

Shen, Liu, Hou, Yang, Wu, Zhang, Li, Che, Lu, Zhang, Liu, Yao: "NDRG2 is highly expressed in pancreatic beta cells and involved in protection against lipotoxicity." in: Cellular and molecular life sciences : CMLS, Vol. 67, Issue 8, pp. 1371-81, 2010 (PubMed).

Chen, Yang, Zheng, Hu, Kong, Zhang: "Effect of catch-up growth after food restriction on the entero-insular axis in rats." in: Nutrition & metabolism, Vol. 7, pp. 45, 2010 (PubMed).

Han, Qiu, Zhang, Kong, Wang, Wang, Li, Duan, Wang, Song, Wang: "Transplantation of sertoli-islet cell aggregates formed by microgravity: prolonged survival in diabetic rats." in: Experimental biology and medicine (Maywood, N.J.), Vol. 234, Issue 5, pp. 595-603, 2009 (PubMed).

Liang, Yin, Zhang, Zhang, Zeng, Wang, Jiang, Yuan, Wang, Li: "Blockade of tumor necrosis factor (TNF) receptor type 1-mediated TNF-alpha signaling protected Wistar rats from diet-induced obesity and insulin resistance." in: Endocrinology, Vol. 149, Issue 6, pp. 2943-51, 2008 (PubMed).

Lu, Gu, Xu, Liu, Xie, Song: "Adult islets cultured in collagen gel transdifferentiate into duct-like cells." in: World journal of gastroenterology, Vol. 11, Issue 22, pp. 3426-30, 2005 (PubMed).

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