MAPT antibody (Microtubule-Associated Protein tau)

Details for Product anti-MAPT Antibody No. ABIN3043669
Antigen
  • DDPAC
  • FTDP-17
  • MAPTL
  • MSTD
  • MTBT1
  • MTBT2
  • PPND
  • TAU
  • AI413597
  • AW045860
  • Mtapt
  • Tau
  • RNPTAU
  • pTau
  • tau
  • xtp
  • MAPT
  • PHF-tau
  • slc6a6
  • taut
  • wu:fc26e12
  • microtubule associated protein tau
  • microtubule-associated protein tau
  • microtubule associated protein tau S homeolog
  • Microtubule-associated protein tau
  • solute carrier family 6 (neurotransmitter transporter), member 6b
  • MAPT
  • Mapt
  • mapt.S
  • LOC5580230
  • CpipJ_CPIJ013260
  • tau
  • slc6a6b
Alternatives
anti-Human MAPT antibody for Western Blotting
Reactivity
Cow (Bovine), Human
1225
803
729
97
39
27
26
20
16
11
8
5
4
4
3
3
3
3
3
2
1
1
1
1
1
Host
Mouse
1166
99
15
7
Clonality (Clone)
Monoclonal ()
Conjugate
This MAPT antibody is un-conjugated
47
21
21
21
21
21
21
12
11
6
6
6
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
1056
450
326
107
82
62
28
21
18
14
13
12
12
12
8
4
2
1
Options
Purpose Mouse IgG monoclonal antibody for Tau, microtubule-associated protein tau (MAPT) detection. Tested with WB, IHC-P in Human,bovine. No cross reactivity with other proteins.
Immunogen Bovine microtubule-associated proteins(MAPs).
Clone TAU-2
Isotype IgG1
Cross-Reactivity (Details) No cross reactivity with other proteins.
Characteristics Mouse IgG monoclonal antibody for Tau, microtubule-associated protein tau (MAPT) detection. Tested with WB, IHC-P in Human,bovine.
Gene Name: microtubule-associated protein tau
Protein Name: Microtubule-associated protein tau
Purification Ascites
Plasmids, Primers & others Plasmids, Primers & others MAPT products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name MAPT (MAPT Antibody Abstract)
Background The microtubule-associated proteins(MAPs) coassemble with tubulin into microtubules in vitro. Microtubule-associated protein tau appears to be enriched in axons. Tau are composed of 352 to 441 amino acids. The isoforms differ from each other by the presence or absence of 29-amino acid or 58-amino acid inserts located in the N terminus and a 31-amino repeat located in the C terminus. tau is important in establishing and maintaining neuronal morphology and is a major component of the neurofibrillary tangles(NFTs) characteristic of Alzheimer's brain. Microtubule-associated protein tau(MTBT1) is mapped to chromosome 17q21.

Synonyms: DDPAC|MAPTL|PHF-tau|FLJ31424|FTDP-17|MGC138549|MSTD|MTBT1|MTBT2|PPND|TAU|G protein beta1/gamma2 subunit-interacting factor 1|microtubule-associated protein tau, isoform 4|Neurofibrillary tangle protein|Paired helical filament-tau
Gene ID 4137, 17762, 29477
UniProt P10636, P10637, P19332
Pathways MAPK Signaling, Microtubule Dynamics, M Phase, Regulation of Cell Size
Application Notes WB: Concentration: 0.5-1 μg/mL, Species: Human, bovine
IHC-P: Concentration: 1-2 μg/mL, Species: Human, bovine
Notes: Other applications have not been tested. Optimal dilutions should be determined by end users.
Comment

Antibody can be supported by chemiluminescence kit ABIN921123 in WB, supported by ABIN921230 in IHC(P).

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 1 mL of PBS buffer will yield a concentration of 100 μg/mL.
Concentration 100 μg/mL
Buffer Mouse ascites fluid, 1.2 % sodium acetate, 2 mg BSA, with 0.01 mg Sodium azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
Supplier Images
Western Blotting (WB) image for anti-Microtubule-Associated Protein tau (MAPT) antibody (ABIN3043669) Anti-Tau antibody (monoclonal), Western blotting Lane 1: Rat Brain Tissue Lysate Lane...
Product cited in: Tang, Yu, Wu, Chen, Zeng, Wang, Yang, Mei, Cao, Qin: "Lychee seed extract protects against neuronal injury and improves cognitive function in rats with type II diabetes mellitus with cognitive impairment." in: International journal of molecular medicine, Vol. 41, Issue 1, pp. 251-263, 2018 (PubMed).

Zhou, Liu, Yuan, Lu: "The expression of insulin-like growth factor-1 in senior patients with diabetes and dementia." in: Experimental and therapeutic medicine, Vol. 13, Issue 1, pp. 103-106, 2017 (PubMed).

Zhu, Li, Yuan, Li, Tian, Jia, Xiao: "Allicin improves endoplasmic reticulum stress-related cognitive deficits via PERK/Nrf2 antioxidative signaling pathway." in: European journal of pharmacology, Vol. 762, pp. 239-46, 2015 (PubMed).

Li, Li, Li, Quan, Wang: "Cellular and molecular mechanisms underlying the action of ginsenoside Rg1 against Alzheimer's disease." in: Neural regeneration research, Vol. 7, Issue 36, pp. 2860-6, 2014 (PubMed).

Tu, Pang, Chen, Zhang, Zhang, Lu, Wang: "Effects of surface charges of graphene oxide on neuronal outgrowth and branching." in: The Analyst, Vol. 139, Issue 1, pp. 105-15, 2013 (PubMed).

Wang, Feng, Fu, Li: "Panax notoginsenoside Rb1 ameliorates Alzheimer's disease by upregulating brain-derived neurotrophic factor and downregulating Tau protein expression." in: Experimental and therapeutic medicine, Vol. 6, Issue 3, pp. 826-830, 2013 (PubMed).

Tan, Cao, Wang, Lv, Wu, Ma: "Protective effects of lithium treatment for spatial memory deficits induced by tau hyperphosphorylation in splenectomized rats." in: Clinical and experimental pharmacology & physiology, Vol. 37, Issue 10, pp. 1010-5, 2010 (PubMed).

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