CACNA1D antibody (AA 1-180)

Catalog No. ABIN3043768

Product Details anti-CACNA1D Antibody

Target: CACNA1D (Calcium Channel, Voltage-Dependent, L Type, alpha 1D Subunit (CACNA1D))

Binding Specificity: AA 1-180

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CACNA1D antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit IgG polyclonal antibody for Voltage-dependent L-type calcium channel subunit alpha-1D(CACNA1D) detection. Tested with WB in Human,Mouse,Rat.

Cross-Reactivity (Details): Predicted Cross Reactivity: human
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Characteristics: Rabbit IgG polyclonal antibody for Voltage-dependent L-type calcium channel subunit alpha-1D(CACNA1D) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: calcium channel, voltage-dependent, L type, alpha 1D subunit
Protein Name: Voltage-dependent L-type calcium channel subunit alpha-1D

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human CaV1.3 recombinant protein (Position: M1-I180). Human CaV1.3 shares 99% and 98%amino acid (aa) sequence identity with mouse and rat CaV1.3, respectively.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Mouse, Rat, Predicted Species: Human, The detection limit for CaV1.3 is approximately 0.1 ng/lane under reducing conditions.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

References for anti-CACNA1D antibody (ABIN3043768)

Guo, Cui, Jiang, Zhang, Jiang: "Proteomics of acute heart failure in a rat post-myocardial infarction model." in: Molecular medicine reports, Vol. 16, Issue 2, pp. 1946-1956, (2018) (PubMed).

Target Details for CACNA1D

Target: CACNA1D (Calcium Channel, Voltage-Dependent, L Type, alpha 1D Subunit (CACNA1D))

Alternative Name: CACNA1D (CACNA1D Products)

Synonyms: cacna1d antibody, cav1.3a antibody, isl antibody, si:dz136d19.3 antibody, si:dz223c6.1 antibody, ca(v)1.3 antibody, cav1.3 antibody, CACH3 antibody, CACN4 antibody, CACNL1A2 antibody, CCHL1A2 antibody, Cav1.3 antibody, SANDD antibody, 8430418G19Rik antibody, C79217 antibody, Cacnl1a2 antibody, Cchl1a antibody, Cchl1a2 antibody, D-LTCC antibody, calcium channel, voltage-dependent, L type, alpha 1D subunit, a antibody, calcium voltage-gated channel subunit alpha1 D antibody, calcium channel, voltage-dependent, L type, alpha 1D subunit antibody, calcium channel, voltage-dependent, L type, alpha 1D subunit L homeolog antibody, cacna1da antibody, CACNA1D antibody, cacna1d antibody, cacna1d.L antibody, Cacna1d antibody

Background: CACNA1D is also known as PASNA, SANDD or Cav1.3. Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene.

Synonyms: alpha-1 polypeptide antibody|CAC1D_HUMAN antibody|CACH3 antibody|CACN4 antibody|CACNA 1D antibody|CACNA1D antibody|CACNL1A2 antibody|Calcium channel antibody|Calcium channel L type alpha 1 polypeptide isoform 2 antibody|Calcium channel neuroendocrine/brain type alpha 1 subunit antibody|Calcium channel voltage dependent L type alpha 1 antibody|Calcium channel voltage dependent L type alpha 1D subunit antibody|Cav1.3 antibody|CCHL1A2 antibody|L type antibody|PASNA antibody|SANDD antibody|Voltage dependent L type calcium channel subunit alpha 1D antibody|Voltage gated calcium channel alpha 1 subunit antibody|Voltage gated calcium channel alpha subunit Cav1.3 antibody|Voltage gated calcium channel subunit alpha Cav1.3 antibody|Voltage-dependent L-type calcium channel subunit alpha-1D antibody|Voltage-gated calcium channel subunit alpha Cav1.3 antibody

Gene ID: 776

UniProt: Q01668

Pathways: Sensory Perception of Sound