CD46 antibody (C-Term)

Catalog No. ABIN3043806

Product Details anti-CD46 Antibody

Target: CD46

Binding Specificity: AA 366-392, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD46 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit IgG polyclonal antibody for Membrane cofactor protein(CD46) detection. Tested with WB, IHC-P in Human.

Sequence: YRYLQRRKKK GTYLTDETHR EVKFTSL

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Membrane cofactor protein(CD46) detection. Tested with WB, IHC-P in Human.
Gene Name: CD46 Molecule, complement regulatory protein
Protein Name: Membrane cofactor protein

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human CD46 (366-392aa YRYLQRRKKKGTYLTDETHREVKFTSL).

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Target Details for CD46

Target: CD46

Alternative Name: CD46 (CD46 Products)

Synonyms: AHUS2 antibody, MCP antibody, MIC10 antibody, TLX antibody, TRA2.10 antibody, Mcp antibody, CD46 antibody, CD46 molecule antibody, CD46 antigen, complement regulatory protein antibody, CD46 molecule, complement regulatory protein antibody, membrane cofactor protein-like antibody, CD46 antibody, Cd46 antibody, LOC100341359 antibody, LOC103789310 antibody

Background: CD46 complement regulatory protein also known as CD46 (cluster of differentiation 46) and Membrane Cofactor Protein is a protein which in humans is encoded by the CD46 gene. The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. And the encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.

Synonyms: AHUS2 antibody|Antigen defined by monoclonal antibody| TRA 2 10 antibody|Antigen identified by monoclonal antibody| TRA 2 10 antibody|CD46 antibody|CD46 antigen antibody|CD46 antigen complement regulatory protein antibody|CD46 Molecule antibody|CD46 Molecule complement regulatory protein antibody|Complement membrane cofactor protein antibody|MCP antibody| MCP_HUMAN antibody|Measles virus receptor antibody|membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen) antibody|Membrane cofactor protein antibody| MGC26544 antibody|MIC10 antibody|TLX antibody|TRA2.10 antibody|Trophoblast leucocyte common antigen antibody|Trophoblast leukocyte common antigen antibody|Trophoblast lymphocyte cross reactive antigen antibody

Gene ID: 4179

UniProt: P15529

Pathways: Regulation of Actin Filament Polymerization