CXCR6 antibody (C-Term)

Catalog No. ABIN3044074

Product Details anti-CXCR6 Antibody

Target: CXCR6 (Chemokine (C-X-C Motif) Receptor 6 (CXCR6))

Binding Specificity: AA 322-342, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CXCR6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit IgG polyclonal antibody for C-X-C chemokine receptor type 6(CXCR6) detection. Tested with WB, IHC-P in Human.

Sequence: EDNSKTFSAS HNVEATSMFQ L

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for C-X-C chemokine receptor type 6(CXCR6) detection. Tested with WB, IHC-P in Human.
Gene Name: chemokine(C-X-C motif) receptor 6
Protein Name: C-X-C chemokine receptor type 6

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Bonzo(322-342aa EDNSKTFSASHNVEATSMFQL), different from the related mouse and rat sequences by three amino acids.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for CXCR6 is approximately 0.5 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Thimerosal (Merthiolate), Sodium azide

Precaution of Use: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for CXCR6

Target: CXCR6 (Chemokine (C-X-C Motif) Receptor 6 (CXCR6))

Alternative Name: CXCR6 (CXCR6 Products)

Synonyms: BONZO antibody, CD186 antibody, STRL33 antibody, TYMSTR antibody, BB217514 antibody, C-X-C motif chemokine receptor 6 antibody, chemokine (C-X-C motif) receptor 6 L homeolog antibody, chemokine (C-X-C motif) receptor 6 antibody, CXCR6 antibody, cxcr6.L antibody, Cxcr6 antibody

Background: CXCR6(Chemokine,CXC Motif, Receptor 6), also known as STRL33, is a protein that in humans is encoded by the CXCR6 gene. By Southern blot analysis of genomic DNA and somatic cell hybrid analysis, Liao et al.(1997) mapped the single-copy STRL33 gene to chromosome 3. Matloubian et al.(2000) found that human and mouse cells expressing CXCR6 showed a strong chemotactic response to CXCL16 but not to other chemokines. The authors concluded that CXCL16 and CXCR6 probably function in interactions between dendritic cells and T cells and in regulating T-cell migration in the splenic red pulp. Kim et al.(2001) concluded that CXCR6 may be important in the trafficking of effector T cells mediating type-1 inflammation.

Synonyms: C X C chemokine receptor type 6 antibody|C-X-C chemokine receptor type 6 antibody|CD 186 antibody|CD186 antibody|CD186 antigen antibody|CDw186 antibody|Chemokine(C X C motif) receptor 6 antibody|Chemokine C X C motif receptor 6 antibody|Chemokine C-X-C Motif Receptor 6 antibody|Chemokine CXC motif receptor 6 antibody|Chemokine receptor 6 antibody|CXC chemokine receptor type 6 antibody|CXC R6 antibody|CXC-R6 antibody|CXCR 6 antibody|CXCR-6 antibody|CXCR6 antibody|CXCR6_HUMAN antibody|G protein coupled receptor antibody|G protein coupled receptor bonzo antibody|G protein coupled receptor STRL 33 antibody|G protein coupled receptor STRL33 antibody|G protein coupled receptor TYMSTR antibody|G-protein coupled receptor bonzo antibody|G-protein coupled receptor STRL33 antibody|STRL 33 antibody|STRL33 antibody|TYMSTR antibody

UniProt: O00574