FMO3 antibody (N-Term)

Catalog No. ABIN3044154

Product Details anti-FMO3 Antibody

Target: FMO3 (Flavin Containing Monooxygenase 3 (FMO3))

Binding Specificity: AA 76-90, N-Term

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FMO3 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit IgG polyclonal antibody for Dimethylaniline monooxygenase[N-oxide-forming] 3(FMO3) detection. Tested with WB in Human,Mouse,Rat.

Sequence: DDFPNFMHNS KIQEY

Cross-Reactivity (Details): Predicted Cross Reactivity: human, mouse
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Characteristics: Rabbit IgG polyclonal antibody for Dimethylaniline monooxygenase[N-oxide-forming] 3(FMO3) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: flavin containing monooxygenase 3
Protein Name: Dimethylaniline monooxygenase [N-oxide-forming] 3

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human FMO3(76-90aa DDFPNFMHNSKIQEY), different from the related rat sequence by one amino acid, and from the related mouse sequence by two amino acids.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Rat, Predicted Species: Human, Mouse
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Thimerosal (Merthiolate), Sodium azide

Precaution of Use: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for FMO3

Target: FMO3 (Flavin Containing Monooxygenase 3 (FMO3))

Alternative Name: FMO3 (FMO3 Products)

Synonyms: MGC107820 antibody, FMOII antibody, TMAU antibody, dJ127D3.1 antibody, FM03 antibody, AW111792 antibody, flavin containing monooxygenase 3 antibody, flavin containing monooxygenase 3 L homeolog antibody, FMO3 antibody, fmo3 antibody, fmo3.L antibody, Fmo3 antibody

Background: FMO3(Flavin-containing Monooxygenase 3) is an enzyme that in humans is encoded by the FMO3 gene. The mammalian flavin-containing monooxygenases(FMO) represent a multigene family whose gene products are localized in the endoplasmic reticulum of many tissues. The FMO3 gene contains 1 noncoding and 8 coding exons. The FMO3 gene is mapped on 1q24.3. Using quantitative RNase protection assays, FMO3 is present in low abundance in fetal liver and lung and in adult kidney and lung, and in much greater abundance in adult liver. By Western blot analysis of human liver microsomal samples ranging from 8 weeks gestation to 18 years of age, FMO1 is the major fetal isoform and FMO3 is the major adult isoform. FMO3 was expressed at intermediate levels until 11 years of age when a gender-independent increase in FMO3 expression was observed during puberty. Sufferers of trimethylaminuria may display a reduced ability to metabolize substrates for FMO3 such as nicotine. FMO3 metabolizes a number of drugs, including amphetamine, clozapine, deprenyl, metamphetamine, tamoxifen, ethionamide, thiacetazone, and sulindac sulfide.

Synonyms: Dimethylaniline monooxygenase[N oxide forming] 3 antibody|Dimethylaniline monooxygenase[N-oxide-forming] 3 antibody|Dimethylaniline monooxygenase 3 antibody|Dimethylaniline oxidase 3 antibody|dJ127D3.1 antibody|Flavin containing monooxygenase 3 antibody|FMO 3 antibody|FMO form 2 antibody|FMO II antibody|FMO3 antibody|FMO3_HUMAN antibody|FMOII antibody|Hepatic flavin containing monooxygenase 3 antibody|Hepatic flavin-containing monooxygenase 3 antibody|MGC34400 antibody|TMAU antibody|Trimethylamine monooxygenase antibody

UniProt: P31513