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SDHB antibody (N-Term)

SDHB Reactivity: Human, Rat WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3044278
  • Target See all SDHB Antibodies
    SDHB (Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB))
    Binding Specificity
    • 16
    • 11
    • 11
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 79
    • 33
    • 21
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Rat
    Host
    • 74
    • 5
    • 2
    Rabbit
    Clonality
    • 64
    • 17
    Polyclonal
    Conjugate
    • 40
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This SDHB antibody is un-conjugated
    Application
    • 62
    • 27
    • 19
    • 13
    • 13
    • 11
    • 10
    • 5
    • 4
    • 3
    • 3
    • 2
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purpose
    Rabbit IgG polyclonal antibody for Succinate dehydrogenase[ubiquinone] iron-sulfur subunit, mitochondrial(SDHB) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Sequence
    FAIYRWDPDK AGDKPHMQ
    Cross-Reactivity (Details)
    Predicted Cross Reactivity: mouse
    No cross reactivity with other proteins.
    Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.
    Characteristics
    Rabbit IgG polyclonal antibody for Succinate dehydrogenase[ubiquinone] iron-sulfur subunit, mitochondrial(SDHB) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Gene Name: succinate dehydrogenase complex, subunit B, iron sulfur(Ip)
    Protein Name: Succinate dehydrogenase[ubiquinone] iron-sulfur subunit, mitochondrial
    Purification
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence at the N-terminus of human SDHB(42-59 FAIYRWDPDKAGDKPHMQ), different from the related rat sequence by one amino acid and mouse sequence by two amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product SDHB Primary Antibody
  • Application Notes
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Comment

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Preservative
    Thimerosal (Merthiolate), Sodium azide
    Precaution of Use
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
    Expiry Date
    12 months
  • Target
    SDHB (Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB))
    Alternative Name
    SDHB (SDHB Products)
    Synonyms
    succinate dehydrogenase 2-3 antibody, CG3283 antibody, Dmel\\CG3283 antibody, Ip antibody, SDH antibody, SDH-IP antibody, SDH-Ip antibody, SDHb antibody, sdhB antibody, CWS2 antibody, IP antibody, PGL4 antibody, SDH1 antibody, SDH2 antibody, SDHIP antibody, 0710008N11Rik antibody, fj46d06 antibody, wu:fj46d06 antibody, succinate dehydrogenase complex iron sulfur subunit B antibody, succinate dehydrogenase [ubiquinone] iron-sulfur subunit 3 antibody, Succinate dehydrogenase, subunit B (iron-sulfur) antibody, succinate dehydrogenase complex subunit B, iron sulfur (Ip) antibody, succinate dehydrogenase complex, subunit B, iron sulfur (Ip) antibody, succinate dehydrogenase complex subunit B, iron sulfur (Ip) S homeolog antibody, SDHB antibody, SDH2-3 antibody, SdhB antibody, sdhb antibody, Sdhb antibody, sdhb.S antibody
    Background
    SDHB(Succinate Dehydrogenase Complex, Subunit B, iron sulfur protein), also known as iron-sulfur subunit of complex II(Ip) or SDH2, HOMOLOG OF, is a protein that in humans is encoded by the SDHB gene. SDHB is one of four protein subunits forming succinate dehydrogenase, the other three being SDHA, SDHC and SDHD. The SDHB subunit is connected to the SDHA subunit on the hydrophilic, catalytic end of the SDH complex. The SDHB gene is mapped on 1p36.13. The entire SDHB transcript is encoded by 8 exons within approximately 40 kb by Au et al(1995). Pollard et al.(2005) stated that the nuclear-encoded Krebs cycle enzymes fumarate hydratase and succinate dehydrogenases like SDHB act as tumor suppressors, and germline mutations in these genes predispose individuals to leiomyomas and renal cancer and to paragangliomas, respectively. In affected members of families with paragangliomas-4, mutations were identified in the SDHB gene.

    Synonyms: CWS2 antibody|DHSB_HUMAN antibody|FLJ92337 antibody|IP antibody|Iron sulfur subunit antibody|Iron sulfur subunit of complex II antibody|Iron-sulfur subunit of complex II antibody|mitochondrial antibody|OTTHUMP00000044624 antibody|PGL 4 antibody|PGL4 antibody|SDH 1 antibody|SDH antibody|SDH1 antibody|SDH2 antibody|SDHB antibody|SDHIP antibody|Succinate dehydrogenase[ubiquinone] iron sulfur protein mitochondrial antibody|Succinate dehydrogenase[ubiquinone] iron-sulfur subunit antibody|succinate dehydrogenase[ubiquinone] iron-sulfur subunit, mitochondrial antibody|Succinate Dehydrogenase 1 Iron Sulfur Subunit antibody|Succinate dehydrogenase complex subunit B iron sulfur antibody|Succinate Dehydrogenase Complex Subunit B Iron Sulfur Protein antibody|succinate dehydrogenase complex, subunit B, iron sulfur(Ip) antibody|Succinate dehydrogenase iron sulfur protein antibody
    UniProt
    P21912
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