TRKA antibody (Neurotrophic Tyrosine Kinase, Receptor, Type 1) (AA 342-361)

Details for Product anti-NTRK1 Antibody No. ABIN3044367
Antigen
  • MTC
  • TRK
  • TRK1
  • TRKA
  • Trk-A
  • p140-TrkA
  • Trk
  • C80751
  • Tkr
  • TrkA
  • trk
  • trka
  • CTRKA
  • trkA
  • neurotrophic receptor tyrosine kinase 1
  • neurotrophic tyrosine kinase, receptor, type 1
  • NTRK1
  • Ntrk1
  • ntrk1
Alternatives
anti-Human TRKA antibody for Immunoprecipitation
Epitope
AA 342-361, Middle Region
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Reactivity
Human, Mouse (Murine), Rat (Rattus)
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Host
Rabbit
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Clonality
Polyclonal
Conjugate
This TRKA antibody is un-conjugated
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Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Options
Purpose Rabbit IgG polyclonal antibody for High affinity nerve growth factor receptor(NTRK1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Immunogen A synthetic peptide corresponding to a sequence in the middle region of human TrkA(342-361aa RHGCLRLNQPTHVNNGNYTL), identical to the related rat and mouse sequences.
Sequence RHGCLRLNQP THVNNGNYTL
Isotype IgG
Cross-Reactivity (Details) No cross reactivity with other proteins.
Characteristics Rabbit IgG polyclonal antibody for High affinity nerve growth factor receptor(NTRK1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: neurotrophic tyrosine kinase, receptor, type 1
Protein Name: High affinity nerve growth factor receptor
Purification Immunogen affinity purified.
Plasmids, Primers & others Plasmids, Primers & others TRKA products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name NTRK1 (NTRK1 Antibody Abstract)
Background Trk A(Neurotrophic tyrosine kinase receptor A) is the high affinity catalytic receptor for the neurotrophin, Nerve Growth Factor(NGF). Higher affinity binding of NGFR can achieved by association with higher molecular mass, low-affinity neurotrophin receptors, namely the tropomyosin receptor kinases, TRKA(NTRK1), TRKB(NTRK2), and TRKC(NTRK3). TRKA, TRKB, and TRKC are specific for or "preferred by" NGF, NTF4(Neurotrophin-4) and BDNF, and NTF3(Neurotrophin-3), respectively. NTF3 also binds to TRKA and TRKB, but with significantly lower affinity. The absence of TrkA(NGFR) expression was associated with a strong increase in the Sp3 repressor short isoform(s) and a lack of the Sp3 activator long isoform. Sp3 is a bifunctional transcription factor that has been reported to stimulate or repress the transcription of numerous genes. Indo et al.(1996) concluded that defects in TRKA cause CIPA(Congenital insensitivity to pain with anhidrosis) and that the NGF-TRKA system has a crucial role in the development and function of the nociceptive reception as well as establishment of thermoregulation via sweating in humans. These results also implicate genes encoding other TRK and neurotrophin family members as candidates for developmental defect(s) of the nervous system.

Synonyms: CIPA antibody|DKFZp781I14186 antibody|gp140trk antibody|High affinity nerve growth factor receptor antibody|High affinity nerve growth factor receptor precursor antibody|MTC antibody|neurotrophic tyrosine kinase receptor type 1 antibody|Ntrk 1 antibody|Ntrk1 antibody|NTRK1_HUMAN antibody|Oncogene TRK antibody|p140 TrkA antibody|p140-TrkA antibody|TRK 1 antibody|Trk A antibody|TRK antibody|Trk-A antibody|TRK1 antibody|TRK1 transforming tyrosine kinase protein antibody|TRK1-transforming tyrosine kinase protein antibody|Tropomyosin-related kinase A antibody|Tyrosine kinase receptor A antibody|Tyrosine kinase receptor antibody|Tyrosine Receptor Kinase A antibody
UniProt P04629
Pathways RTK Signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process
Application Notes WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
Comment

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
Concentration 500 μg/mL
Buffer Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
Preservative Thimerosal (Merthiolate), Sodium azide
Precaution of Use This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 342-361), (Middle Region) antibody (ABIN3044367) Anti-TrkA antibody, Western blotting Lane 1: Rat Brain Tissue Lysate Lane 2: Mouse Br...
Immunohistochemistry (IHC) image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (AA 342-361), (Middle Region) antibody (ABIN3044367) Anti-TrkA antibody, IHC(P) IHC(P): Rat Brain Tissue
Product cited in: Li, Ma, Yi, Wang, Li, Liu, Sun, Chen, Yu, Li, Chen, Zhou: "The interactions between nerve growth factor and gonadotrophins in bovine oviduct." in: Animal reproduction science, Vol. 149, Issue 3-4, pp. 117-23, 2014 (PubMed).

Li, Zhang, Zou, Xia, Bao: "Accumulation of nerve growth factor and its receptors in the uterus and dorsal root ganglia in a mouse model of adenomyosis." in: Reproductive biology and endocrinology : RB&E, Vol. 9, pp. 30, 2011 (PubMed).

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