SERPINA3 antibody (Middle Region)

Catalog No. ABIN3044487

Product Details anti-SERPINA3 Antibody

Target: SERPINA3 (serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 3 (SERPINA3))

Binding Specificity: AA 218-232, Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SERPINA3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit IgG polyclonal antibody for Alpha-1-antichymotrypsin(SERPINA3) detection. Tested with WB, IHC-P in Human.

Sequence: EMPFDPQDTH QSRFY

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Alpha-1-antichymotrypsin(SERPINA3) detection. Tested with WB, IHC-P in Human.
Gene Name: serpin peptidase inhibitor, clade A(alpha-1 antiproteinase, antitrypsin), member 3
Protein Name: Alpha-1-antichymotrypsin

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human alpha 1 Antichymotrypsin(218-232aa EMPFDPQDTHQSRFY).

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Thimerosal (Merthiolate), Sodium azide

Precaution of Use: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for SERPINA3

Target: SERPINA3 (serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 3 (SERPINA3))

Alternative Name: SERPINA3 (SERPINA3 Products)

Synonyms: SERPINA3-1 antibody, Pi2 antibody, AACT antibody, ACT antibody, GIG25 antibody, A1AT antibody, PI antibody, alpha-1-PI antibody, AAT antibody, Pi antibody, Spi1 antibody, SERPINA3-5 antibody, serpina3 antibody, serpin A3-5 antibody, serpin family A member 3 antibody, alpha-1-antiproteinase F precursor antibody, serpin family A member 1 antibody, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 antibody, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 antibody, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 L homeolog antibody, LOC396684 antibody, SERPINA3 antibody, LOC100008973 antibody, SERPINA1 antibody, Serpina1 antibody, SPIA5 antibody, serpina3.L antibody

Background: Alpha 1-antichymotrypsin, also called serpin peptidase inhibitor, clade A(alpha-1 antiproteinase, antitrypsin), member 3 or GIG24 is an alpha globulin glycoprotein that is a member of the serpin superfamily. In humans, it is encoded by the SERPINA3 gene. This gene is mapped to 14q32.13. The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease.

Synonyms: SERPINA3 antibody|AACT antibody|AACT_HUMAN antibody|ACT antibody|Alpha 1 Antichymotrypsin 1 antibody|Alpha 1 Antichymotrypsin 2 antibody|Alpha 1 Antichymotrypsin 3 antibody|Alpha 1 Antitrypsin Deficiency antibody|Alpha-1-antichymotrypsin His-Pro-less antibody|Anti Elastase antibody|Antichymotrypsin antibody|Cell growth inhibiting gene 24/25 protein antibody|Cell growth-inhibiting gene 24/25 protein antibody|Clade A(Alpha 1 Antiproteinase Antitrypsin) antibody|GIG24 antibody|GIG25 antibody|Growth inhibiting protein 24 antibody|Growth inhibiting protein 25 antibody|MGC88254 antibody|PI1 antibody|Protease Inhibitor 1 antibody|Serine(or Cysteine) Proteinase Inhibitor antibody|Serine(or cysteine) proteinase inhibitor clade A(alpha 1 antiproteinase, antitrypsin) member 3 antibody|Serine(or cysteine) proteinase inhibitor clade A member 3 antibody|Serine proteinase inhibitor clade A member 3 antibody|Serpin A3 antibody|Serpin peptidase inhibitor clade A(alpha 1 antiproteinase antitrypsin) member 3 antibody|SERPINA1 antibody|SERPINA2 antibody|SERPINA3 antibody

UniProt: P01011