TRIB2 antibody (Middle Region)

Catalog No. ABIN3044555

Product Details anti-TRIB2 Antibody

Target: TRIB2 (Tribbles Pseudokinase 2 (TRIB2))

Binding Specificity: AA 175-211, Middle Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIB2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit IgG polyclonal antibody for Tribbles homolog 2(TRIB2) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Sequence: DLKLRKFIFK DEERTRVKLE SLEDAYILRG DDDSLSD

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Tribbles homolog 2(TRIB2) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: tribbles pseudokinase 2
Protein Name: Tribbles homolog 2

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human TRIB2 (175-211aa DLKLRKFIFKDEERTRVKLESLEDAYILRGDDDSLSD), identical to the related mouse sequence.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Target Details for TRIB2

Target: TRIB2 (Tribbles Pseudokinase 2 (TRIB2))

Alternative Name: TRIB2 (TRIB2 Products)

Synonyms: TRIB2 antibody, Trb2 antibody, Xtrbl antibody, gs3955 antibody, c5fw antibody, trb2 antibody, xtrb2 antibody, TRB2 antibody, C5FW antibody, GS3955 antibody, TRB-2 antibody, AW319517 antibody, RGD1564451 antibody, tribbles pseudokinase 2 antibody, tribbles pseudokinase 2 S homeolog antibody, TRIB2 antibody, trib2 antibody, trib2.S antibody, Trib2 antibody

Background: Tribbles homolog 2 is a protein that in humans is encoded by the TRIB2 gene. This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBP alpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene.

Synonyms: C5FW antibody|FLJ57420 antibody|GS3955 antibody|Hypothetical protein TRB2 antibody|TRB-2 antibody|TRB2 antibody|TRIB 2 antibody|TRIB2 antibody|TRIB2_HUMAN antibody|Tribbles homolog 2 antibody

Gene ID: 28951

UniProt: Q92519