Glyco Protein G antibody

Catalog No. ABIN305114

Product Details

Target: Glyco Protein G

Reactivity: Rabies Virus

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)

Specificity: Recognizes the glycoprotein of rabies virus, a Lyssavirus that causes rabies in mammals. The virus is found in the saliva of infected animals and is mostly spread though bites. The virus then travels though the peripheral nervous system to the central nervous system. Once it reaches the brain it causes acute encephalitis. Symptoms include paralysis, cerebral dysfunction, anxiety, insomnia, confusion, anger, paranoia, terror and hallucination. The production of a large amount of saliva, the inability to speak or swallow and associated hydrophobia is also common in the later stages of the disease. The time between exposure to the virus and onset of symptoms can range from about 2 weeks to several months. Once symptoms appear, death is virtually inevitable. However, the disease can be effectively treated by post-exposure prophylaxis, through vaccination, provided this is done as soon as possible. Recognizes the purified glycoprotein of the rabies virus as well as the native virus. It has been shown to react with intact infected BHK cells and has therapeutic effect on infected mice. The antibody has virus-neutralizing activity with several rabies virus strains such as CVS, Lagos bat, Mokola, Flury LEP and Duvenhage.

Purification: Affinity purified

Immunogen: Purified rabies virus.

Type of Immunogen: Virus

Clone: 1C5

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Target Species of Antibody: Rabies Virus

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS,  pH 7.4, 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.

Target Details

Target: Glyco Protein G

Alternative Name: Rabies Virus Glycoprotein

Synonyms: transmembrane glycoprotein G antibody, RABVgp4 antibody

Target Type: Viral Protein