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NOTUM antibody

NOTUM Reactivity: Human WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN307025
  • Target See all NOTUM Antibodies
    NOTUM (Notum Pectinacetylesterase Homolog (NOTUM))
    Reactivity
    • 38
    • 3
    • 2
    Human
    Host
    • 38
    Rabbit
    Clonality
    • 38
    Polyclonal
    Conjugate
    • 10
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NOTUM antibody is un-conjugated
    Application
    • 34
    • 21
    • 13
    • 13
    • 5
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Cross-Reactivity
    Human, Mouse
    Characteristics
    Pectinacetylesterase homolog, Wingful (Wf),Genetic studies in Drosophila have revealed a novel secreted antagonist for Wingless (Wg) signaling, referred to as Notum/Wingful (Wf). Wf/Notum encodes a protein of 430 amino acid residues, which is related to plant pectin acetylesterases of the / -hydrolase superfamily. The main target of Notum action appears to be cell surface proteoglycans Dally and/or Dally-like (Dlp). Notum governs the extracellular Wg morphogen distribution via Dally and Dlp. Also, like some vertebrate Wnt antagonists, notum expression is activated by Wg signaling, revealing the existence of a feedback control mechanism in which Wg modifies its own gradient distribution. In vertebrate, proteoglycans related to Dally and Dlp likely play important roles in Wnt signaling which encodes a glypican that is required for Wnt-11 signaling. A single ortholog of Notum exists in the mouse and the human genome, implying that a similar regulatory mechanism may exist in vertebrates.
    Purification
    Ammonium Sulfate Precipitation
    Immunogen
    Rabbits were immunized with recombinant full-length notum protein from mouse.
    Isotype
    IgG
    Top Product
    Discover our top product NOTUM Primary Antibody
  • Application Notes
    Antibody can be used for Western blotting (5-10 μg/mL) and immunohistochemistry. Optimal concentration should be evaluated by serial dilutions.
    Restrictions
    For Research Use only
  • Buffer
    Provided as solution in phosphate buffered saline with 0.08 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
  • Target
    NOTUM (Notum Pectinacetylesterase Homolog (NOTUM))
    Alternative Name
    Notum (NOTUM Products)
    Synonyms
    5730593N15Rik antibody, RGD1307119 antibody, notum, palmitoleoyl-protein carboxylesterase antibody, notum pectinacetylesterase homolog (Drosophila) antibody, NOTUM, palmitoleoyl-protein carboxylesterase antibody, NOTUM antibody, Notum antibody
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