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Macrophage Mannose Receptor 1 antibody

MRC1 Reactivity: Human IHC (fro) Host: Mouse Monoclonal 30-06-50 unconjugated
Catalog No. ABIN316963
  • Target See all Macrophage Mannose Receptor 1 (MRC1) Antibodies
    Macrophage Mannose Receptor 1 (MRC1) (Mannose Receptor, C Type 1 (MRC1))
    Reactivity
    • 62
    • 38
    • 23
    • 16
    • 1
    • 1
    Human
    Host
    • 43
    • 21
    • 12
    Mouse
    Clonality
    • 41
    • 31
    Monoclonal
    Conjugate
    • 34
    • 8
    • 8
    • 6
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Macrophage Mannose Receptor 1 antibody is un-conjugated
    Application
    • 53
    • 40
    • 23
    • 16
    • 13
    • 11
    • 9
    • 8
    • 6
    • 5
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificity
    This antibody is specific for CD206, otherwise known as Macrophage Mannose Receptor (MMR).
    Cross-Reactivity (Details)
    Species reactivity (tested):Human.
    Characteristics
    Synonyms: Macrophage mannose receptor 1, MMR, Dendritic Cell Marker, CLEC13D, Mannose ReceptorC type 1, C-type lectin domain family 13
    Purification
    Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
    Immunogen
    Monocyte-derived dendritic cells. Remarks: Spleen cells from immunised Balb/c mice were fused with cells of theX63-Ag8. 653 myeloma cell line.
    Clone
    30-06-50
    Isotype
    IgG2a
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    Discover our top product MRC1 Primary Antibody
  • Application Notes
    Immunohistochemistry on Frozen Sections: 1/50-1/500. Positive Control: Human Tonsil.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS, 0.09 % Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
    Shelf life: one year from despatch.
    Expiry Date
    12 months
  • Grønbæk, Rødgaard-Hansen, Aagaard, Arroyo, Moestrup, Garcia, Solà, Domenicali, Piano, Vilstrup, Møller: "Macrophage activation markers predict mortality in patients with liver cirrhosis without or with acute-on-chronic liver failure (ACLF)." in: Journal of hepatology, Vol. 64, Issue 4, pp. 813-22, (2016) (PubMed).

    Vilahur, Cubedo, Padró, Casaní, Juan-Babot, Crespo, Bendjama, Lawton, Badimon: "Roflumilast-induced Local Vascular Injury Is Associated with a Coordinated Proteome and Microparticle Change in the Systemic Circulation in Pigs." in: Toxicologic pathology, Vol. 43, Issue 4, pp. 569-80, (2016) (PubMed).

    Rødgaard-Hansen, Rafique, Christensen, Maniecki, Sandahl, Nexø, Møller: "A soluble form of the macrophage-related mannose receptor (MR/CD206) is present in human serum and elevated in critical illness." in: Clinical chemistry and laboratory medicine, Vol. 52, Issue 3, pp. 453-61, (2014) (PubMed).

    Andersen, Krzystanek, Petersen, Bomholtz, Olesen, Abriel, Jespersen, Rasmussen: "A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein." in: The Journal of biological chemistry, Vol. 288, Issue 52, pp. 36841-54, (2014) (PubMed).

    Silk, Leishman, Nishimoto, Reddy, Fairchild: "Rapamycin conditioning of dendritic cells differentiated from human ES cells promotes a tolerogenic phenotype." in: Journal of biomedicine & biotechnology, Vol. 2012, pp. 172420, (2012) (PubMed).

    Winkler, Doster, Jones: "Bovine herpesvirus 1 can infect CD4(+) T lymphocytes and induce programmed cell death during acute infection of cattle." in: Journal of virology, Vol. 73, Issue 10, pp. 8657-68, (1999) (PubMed).

  • Target
    Macrophage Mannose Receptor 1 (MRC1) (Mannose Receptor, C Type 1 (MRC1))
    Alternative Name
    CD206 / MRC1 (MRC1 Products)
    Synonyms
    CD206 antibody, CLEC13D antibody, CLEC13DL antibody, MMR antibody, MRC1L1 antibody, bA541I19.1 antibody, AW259686 antibody, MR antibody, mrc1 antibody, MGC86525 antibody, MRC1 antibody, MRC1L-A antibody, mannose receptor C-type 1 antibody, mannose receptor, C type 1 antibody, mannose receptor C-type 1 L homeolog antibody, mediator of replication checkpoint 1 antibody, MRC1 antibody, Mrc1 antibody, mrc1.L antibody, mrc1 antibody
    Background
    CD206 is a transmembrane protein and member of the multilectin family of pattern recognition receptors (PRRs), which mediates phagocytosis and endocytosis, and is modulated by a range of factors including cytokines, immunoglobulin receptors and pathogens. CD206 has two extracellular lectin binding sites: the cysteine-rich domain binds to sulphated sugars of glycoproteins such as thyroid stimulating hormone, whilst the recognition of mannose and fucose occurs through carbohydrate recognition domains (CRDs). The widespread distribution and recognition of a wide range of antigens by macrophages, plays a key role in both innate and adaptive immunity, with CD206 able to bind to both gram-negative and gram-positive bacteria, mycobacterium, yeasts, fungi and parasites. The expression of CD206 is not restricted to macrophages, but is also present on immature dendritic cells (DCs), endothelial cells, kidney mesangial cells, retinal pigment epithelium and tracheal smooth muscle cells.Synonyms: C-type lectin domain family 13 member D, C-type lectin domain family 13 member D-like, CLEC13D, CLEC13DL, MRC1L1, Macrophage mannose receptor, Macrophage mannose receptor 1-like protein 1
    UniProt
    P22897
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