ACVRL1 antibody

Catalog No. ABIN317607

Product Details anti-ACVRL1 Antibody

Target: ACVRL1 (Activin A Receptor Type II-Like 1 (ACVRL1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ACVRL1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Specificity: This antibody detects endogenous levels of ALK-1 protein (region surrounding Phe231)

Purification: Affinity Chromatography using epitope-specific immunogen

Application Details

Application Notes: Western Blot: 1/500-1/1000. ELISA: 1/20000-1/40000. Immunohistochemistry: 1/50-1/200. Immunofluorescence: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, pH ~7.2, 0.05 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for ACVRL1

Target: ACVRL1 (Activin A Receptor Type II-Like 1 (ACVRL1))

Alternative Name: ACVRL1 / ALK1 (ACVRL1 Products)

Synonyms: ACVRL1 antibody, vgb antibody, alk1 antibody, zehn1109 antibody, hm:zehn1109 antibody, ACVRLK1 antibody, ALK-1 antibody, ALK1 antibody, HHT antibody, HHT2 antibody, ORW2 antibody, SKR3 antibody, TSR-I antibody, R-3 antibody, R3 antibody, SETHKIR antibody, AI115505 antibody, AI427544 antibody, Acvrlk1 antibody, Alk1 antibody, activin A receptor like type 1 antibody, activin A receptor type II-like 1 antibody, activin A receptor, type II-like 1 antibody, ACVRL1 antibody, acvrl1 antibody, Acvrl1 antibody

Background: ACVRL1 is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. This protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.Synonyms: ACVRLK1, Activin A receptor type II-like 1, Activin receptor-like kinase 1, SKR3, Serine/threonine-protein kinase receptor R3, TGF-B superfamily receptor type I

Molecular Weight: approx. 56 kDa

Gene ID: 94

NCBI Accession: NP_000011

UniProt: P37023