PHLDA1 antibody

Catalog No. ABIN317621

Product Details anti-PHLDA1 Antibody

Target: PHLDA1 (Pleckstrin Homology-Like Domain, Family A, Member 1 (PHLDA1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PHLDA1 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody detects endogenous levels of TDAG51 protein.(region surrounding Ala149)

Purification: Affinity Chromatography using epitope-specific immunogen.

Application Details

Application Notes: ELISA: 1/10000-1/20000. Western Blot: 1/500-1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2 containing 0,05 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PHLDA1

Target: PHLDA1 (Pleckstrin Homology-Like Domain, Family A, Member 1 (PHLDA1))

Alternative Name: TDAG51 / PHLDA1 (PHLDA1 Products)

Synonyms: DT1P1B11 antibody, PHRIP antibody, TDAG51 antibody, Tdag antibody, pleckstrin homology like domain family A member 1 antibody, pleckstrin homology like domain, family A, member 1 antibody, pleckstrin homology-like domain, family A, member 1 antibody, pleckstrin homology-like domain, family A, member 1 L homeolog antibody, PHLDA1 antibody, Phlda1 antibody, phlda1.L antibody

Background: Cytotoxic T lymphocyte (CTL)-mediated cytotoxicity constitutes an important component of specific effector mechanisms in immunosurveillance against virus-infected or -transformed cells. Two mechanisms appear to account for this activity, one of which is the perforin-based process. Independently, a FAS-based mechanism involves the transducing molecule FAS (APO-1) and its ligand (FAS-L). The human FAS (APO-1) protein is a 48 kDa cell surface glycoprotein that belongs to a family of receptors that includes CD40, nerve growth factor receptors and tumor necrosis factor receptors. The FAS antigen is expressed on a broad range of lymphoid cell lines, and is expressed at high levels in T cells subsequent to crosslinking of the T cell receptor (TCR). A previously undescribed protein, TDAG51, restores activation- induced apoptosis in cells that have lost the ability to display Fas in response to activation. Thus, TDAG51 plays a critical role in T cell apoptosis by coupling TCR.Synonyms: Apoptosis-associated nuclear protein, PHRIP, PQ-rich protein, PQR protein, Pleckstrin homology-like domain family A member 1, Proline- and glutamine-rich protein, Proline- and histidine-rich protein, T-cell death-associated gene 51 protein

Gene ID: 22822

NCBI Accession: NP_031376

UniProt: Q8WV24