SERPINA5 antibody

Catalog No. ABIN317849

Product Details anti-SERPINA5 Antibody

Target: SERPINA5 (serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 5 (SERPINA5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SERPINA5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: PAI-3 antibody detects endogenous levels of PAI-3 protein.(region surrounding Leu291)

Purification: Affinity chromatography

Application Details

Application Notes: ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for SERPINA5

Target: SERPINA5 (serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 5 (SERPINA5))

Alternative Name: SERPINA5 (SERPINA5 Products)

Synonyms: 4933415L04 antibody, PAI-3 antibody, Pci antibody, PAI3 antibody, PCI antibody, PCI-B antibody, PLANH3 antibody, PROCI antibody, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 antibody, serpin family A member 5 antibody, serine (or cysteine) peptidase inhibitor, clade A, member 5 antibody, plasma serine protease inhibitor antibody, SPIA5 antibody, SERPINA5 antibody, Serpina5 antibody, LOC480424 antibody

Background: PAI-1, PAI-2 and PAI-3 (plasminogen activator inhibitor-1, -2 and -3) are members of the serpin serine proteinase inhibitor family. PAI-1 and PAI-2 regulate uPA (urokinase-type plasminogen activator) and TPA (tissue plasminogen activator), resulting in the inhibition of proteolytic activity. Members of the serpin family generally complex with their target proteinases, then disassociate slowly into cleaved species that fold into stable inactive forms. PAI-1 can fold into the inactive state without cleavage resulting in the latent form of PAI-1. Activity can be restored to the latent form of PAI-1 through denaturation and renaturation. PAI-2 occurs in secreted and cytosolic forms through facultative polypeptide translocation. PAI-3 inhibits plasminogen activators as well as activated protein C. PAI-3 is secreted in plasma, but is also expressed in liver.Synonyms: Acrosomal serine protease inhibitor, PAI-3, PAI3, PCI, PLANH3, PROCI, Plasma serine protease inhibitor, Plasminogen activator inhibitor 3, Protein C inhibitor, Serpin A5

Molecular Weight: approx. 42 kDa

Gene ID: 5104

NCBI Accession: NP_000615

UniProt: P05154