Prostacyclin Receptor antibody

Catalog No. ABIN317863

Product Details anti-Prostacyclin Receptor Antibody

Target: Prostacyclin Receptor (PTGIR)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Prostacyclin Receptor antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Specificity: IP Receptor antibody detects endogenous levels of IP Receptor protein.(region surrounding His237)

Purification: Affinity chromatography

Application Details

Application Notes: ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Prostacyclin Receptor

Target: Prostacyclin Receptor (PTGIR)

Alternative Name: Prostacyclin Receptor / PTGIR (PTGIR Products)

Synonyms: IP antibody, PGI2 antibody, PRIPR antibody, prostaglandin I receptor (IP) antibody, prostaglandin I2 receptor antibody, Ptgir antibody, PTGIR antibody

Background: Cyclooxygenases metabolize arachidonate to five primary prostanoids: PGE2, PGF2α, PGI2, TXA2 and PGD2. These lipid mediators interact with specific members of G protein-coupled prostanoid receptors, designated EP, FP, IP, TP and DP, respectively. The IP Receptor binds prostacyclin, PGI2, the main prostanoid synthesized by vascular tissues. First discovered in 1976, prostacyclin is involved in platelet aggregation inhibition, vasodilatation and cytoprotection, and either prostacyclin or its analogs are used in the treatment of hypertension. Upon binding to the IP Receptor, prostacyclin activates adenylate cyclase primarily through the Gas protein. The gene encoding the human IP Receptor is located on chromosome 19. It is expressed as a glycosylated and phosphorylated protein, which is abundantly expressed in vascular tissues such as aorta, lung, atrium and ventricle, as well as in kidney, thymus, spleen and neurons.Synonyms: PGI receptor, PRIPR, Prostaglandin I2 receptor, Prostanoid IP receptor

Molecular Weight: approx. 45 kDa

Gene ID: 5739

NCBI Accession: NP_000951

UniProt: P43119

Pathways: cAMP Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Thromboxane A2 Receptor Signaling