OXER1 antibody

Catalog No. ABIN317873

Product Details anti-OXER1 Antibody

Target: OXER1 (Oxoeicosanoid Receptor 1 (OXER1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OXER1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: TG1019 antibody detects endogenous levels of TG1019 protein.(region surrounding Arg251)

Purification: Affinity chromatography

Application Details

Application Notes: ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for OXER1

Target: OXER1 (Oxoeicosanoid Receptor 1 (OXER1))

Alternative Name: Oxoeicosanoid Receptor 1 (OXER1 Products)

Synonyms: GPCR antibody, GPR170 antibody, TG1019 antibody, oxoeicosanoid receptor 1 antibody, OXER1 antibody

Background: TG1019 is a G protein-coupled receptor that functions as a chemoattractant for eosinophils and neutrophils. TG1019 is expressed in various tissues except the brain, with the highest expression in liver, kidney, peripheral leukocyte, lung and spleen. TG1019 interacts with the protein OXE to form TG1019/OXE, a Gα i/o protein-coupled receptor. Signals from TG1019 are transduced via a Gα i/o protein to PLC/calcium, MEK/ERK and PI3K/Akt pathways. Signal transduction from TG1019 following stimulation with 5-oxo-6E,8Z,11Z,14Z eicosatetraenoic acid (5-oxo-ETE) induces intracellular calcium mobilization and rapid activation of MEK/ERK and PI3K/Akt pathways. TG1019 also may play a role in downregulating cAMP production.Synonyms: 5-oxo-ETE G-protein coupled receptor, GPR170, OXER1, R527, TG1019

Molecular Weight: approx. 46 kDa

Gene ID: 165140

NCBI Accession: NP_683765

UniProt: Q8TDS5

Pathways: cAMP Metabolic Process