Stim2 antibody (Middle Region)

Catalog No. ABIN318882

Product Details anti-Stim2 Antibody

Target: Stim2 (Stromal Interaction Molecule 2 (Stim2))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Stim2 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody recognises an internal region of stromal interaction molecule-2 (STIM2), a ubiquitously expressed type I membrane protein, of which at least three isoforms have been identified.

Purification: Purified

Immunogen: A 17 amino acid peptide located near the centre of human STIM2.

Isotype: IgG

Application Details

Application Notes: Western Blot: 0.5 - 1.0 μg/mL, detects a band of approximately 105 kDa in A20 cell lysates
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline containing 0.02 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for Stim2

Target: Stim2 (Stromal Interaction Molecule 2 (Stim2))

Alternative Name: STIM2 (Stim2 Products)

Synonyms: STIM2 antibody, stromal interaction molecule 2 antibody, STIM2 antibody, stim2 antibody, Stim2 antibody

Background: In T-lymphocytes and other haematopoietic cells, the mechanism for increasing intracellular Ca2+, following antigen mediated T-cell activation, is through the store-operated Ca2+ release-activated Ca2+ (CRAC) channels. STIM1 is reported to activate CRAC channels upon Ca2+ depletion. Whereas, STIM2 acts to inhibit the STIM1-mediated store-operated Ca2+ entry, and forms complexes with STIM1, suggesting that these molecules may play a co-ordinated role in controlling Ca2+ entry.Synonyms: KIAA1482, Stromal interaction molecule 2

Gene ID: 57620

NCBI Accession: NP_065911

UniProt: Q9P246

Pathways: TCR Signaling, BCR Signaling