Growth Hormone Receptor antibody (GHR) (AA 1-265)

Details for Product anti-GHR Antibody No. ABIN3218228, Supplier: Log in to see
Antigen
  • GHBP
  • AA986417
  • GHR/BP
  • GHR
  • ghr
  • growth hormone receptor
  • growth hormone receptor L homeolog
  • GHR
  • Ghr
  • ghr.L
  • ghr
Alternatives
anti-Human Growth Hormone Receptor antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
AA 1-265
15
10
5
4
4
4
4
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Rat (Rattus)
76
45
40
17
2
2
1
1
1
Host
Rabbit
79
15
2
Clonality
Polyclonal
Conjugate
This Growth Hormone Receptor antibody is un-conjugated
4
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA
59
31
16
13
11
11
5
5
2
2
2
1
1
1
Options
Supplier
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Immunogen Recombinant Rat Growth Hormone Receptor / GHR / GHBP Protein (ABIN2009068)
Isotype IgG
Specificity Rat Growth Hormone Receptor / GHR / GHBP
Characteristics Produced in rabbits immunized with purified, recombinant Rat Growth Hormone Receptor / GHR / GHBP (rR Growth Hormone Receptor / GHR / GHBP, ABIN2009068 P16310-1, Met 1-Arg 265,. Growth Hormone Receptor / GHR / GHBP specific IgG was purified by Rat Growth Hormone Receptor / GHR / GHBP affinity chromatography.
Purification purified by affinity chromatography
Sterility 0.2 μm filtered
Plasmids, Primers & others Plasmids, Primers & others Growth Hormone Receptor products on genomics-online (e.g. as negative or positive controls)
Alternative Name GHR (GHR Antibody Abstract)
Background Growth hormone receptor, also known as GH receptor, Somatotropin receptor and GHR, is a single-pass type I, membrane protein which belongs to the,type I, cytokine receptor family and type 1 subfamily. GHR contains one,fibronectin type-III domain. Growth hormone receptor / GHR is expressed in various tissues with high expression in liver and skeletal muscle. Isoform,4,of GHR is predominantly expressed in kidney, bladder, adrenal gland and brain stem. Isoform,1 expression of GHR in placenta is predominant in chorion and decidua. Isoform,4,is highly expressed in placental villi. Isoform,2,of GHR is expressed in lung, stomach and muscle. Growth hormone receptor / GHR is a receptor for pituitary gland growth hormone. It is involved in regulating postnatal body growth. On ligand binding, it couples to the JAK2 / STAT5 pathway. Isoform,2,of GHR up- regulates the production of GHBP and acts as a negative inhibitor of GH signaling. Defects in GHR are a cause of Laron syndrome (LARS) which is a severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone. Defects in GHR may also be a cause of idiopathic short stature autosomal (ISSA) which is defined by a subnormal rate of growth.
UniProt P16310-1
Pathways NF-kappaB Signaling, JAK-STAT Signaling, Response to Growth Hormone Stimulus
Application Notes ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Rat GHR. The detection limit for Rat GHR is approximately 0.00245 ng/well.
Restrictions For Research Use only
Format Liquid
Buffer 0.2 μm filtered solution in PBS with 5 % trehalose
Preservative Without preservative
Handling Advice Avoid repeated freeze-thaw cycles.
Storage 4 °C,-20 °C,-80 °C
Storage Comment This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Expiry Date 12 months
Background publications Faustino, Miranda, do Céu Silva, Alves, Picanço, Ferreira, Seixas, Pina, Romão: "Hb Yaoundé [beta134(H12)Val-->Ala] in association with Hb C [beta6(A3)Glu-->Lys] in a Caucasian Portuguese family." in: Hemoglobin, Vol. 28, Issue 3, pp. 229-35, 2004 (PubMed).

Jorge, Souza, Arnhold, Mendonca et al.: "The first homozygous mutation (S226I) in the highly-conserved WSXWS-like motif of the GH receptor causing Laron syndrome: supression of GH secretion by GnRH analogue therapy not restored by ..." in: Clinical endocrinology, Vol. 60, Issue 1, pp. 36-40, 2003 (PubMed).

Enberg, Luthman, Segnestam, Ritzén, Sundström, Norstedt: "Characterisation of novel missense mutations in the GH receptor gene causing severe growth retardation." in: European journal of endocrinology / European Federation of Endocrine Societies, Vol. 143, Issue 1, pp. 71-6, 2000 (PubMed).

Pantel, Machinis, Sobrier, Duquesnoy, Goossens, Amselem: "Species-specific alternative splice mimicry at the growth hormone receptor locus revealed by the lineage of retroelements during primate evolution." in: The Journal of biological chemistry, Vol. 275, Issue 25, pp. 18664-9, 2000 (PubMed).

Sobrier, Dastot, Duquesnoy, Kandemir, Yordam, Goossens, Amselem: "Nine novel growth hormone receptor gene mutations in patients with Laron syndrome." in: The Journal of clinical endocrinology and metabolism, Vol. 82, Issue 2, pp. 435-7, 1997 (PubMed).

Leung, Spencer, Cachianes, Hammonds, Collins, Henzel, Barnard, Waters, Wood: "Growth hormone receptor and serum binding protein: purification, cloning and expression." in: Nature, Vol. 330, Issue 6148, pp. 537-43, 1988 (PubMed).

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