Poliovirus Receptor antibody (PVR) (AA 1-345) (FITC) Primary Antibody
PVR Reactivity: Mouse FACS Host: Rabbit Monoclonal 305
Catalog No. ABIN3218644
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- Binding Specificity
- AA 1-345
- This Poliovirus Receptor antibody is conjugated to FITC
- Flow Cytometry (FACS)
- Mouse CD155 / PVR
No cross-reactivity in ELISA with
Human LDLR / LDL Receptor
Rat LDLR / LDL Receptor
Cynomolgus LDLR / LDL Receptor
- No Cross-Reactivity
- Human, Rat (Rattus)
- This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD155 / PVR (rM CD155 / PVR, ABIN2007583 NP_081790.1, Met 1-Arg 345, and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
- Recombinant Mouse CD155 protein (ABIN2007583)
- Application Notes
- Optimal working dilution should be determined by the investigator.
- For Research Use only
- 0.1 mg/mL
- Aqueous solution containing 0.5 % BSA and 0.09 % sodium azide
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal
- 4 °C
- Storage Comment
- This antibody is stable for 12 months from date of receipt when stored at 2°C-8°C. Protected from prolonged exposure to light. Do not freeze !
Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
- Expiry Date
- 12 months
- Alternative Name
- PVR (PVR Antibody Abstract)
- CD155, also known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the nectins and nectin-like (Necl) subfamily of immunoglobulin superfamily. This protein contains three Ig-like extracellular domains, a transmembrane segment, and a cytoplasmic tail. In humans, CD155 is predominately expressed by enterocytes and cells of gastrointestinal lymphatic tissues and originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. The normal cellular function of CD155 maybe the involvement of intercellular adhension between epithelial cells. Alternate splicing of the CD155 mRNA yields four different isoforms (α, β, γ, and δ) with the identical extracellular domains. CD155-β and-γ are secreted, whereas the membrane-bound CD155-α and -δ serve as PV receptors. In addition, it has been demonstrated that CD155 can be recognized and bond by DNAM-1 and CD96 which promote the adhension, migration and NK-cell killing, and thus efficiently prime cell- mediated tumor-specific immunity.
- NCBI Accession
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Cancer Immune Checkpoints, SARS-CoV-2 Protein Interactome
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