TRPV4 antibody (Transient Receptor Potential Cation Channel, Subfamily V, Member 4) (1st Cytoplasmic Loop)

Details for Product anti-TRPV4 Antibody No. ABIN350217
Antigen
  • wu:fp52e02
  • CMT2C
  • HMSN2C
  • OTRPC4
  • SMAL
  • SPSMA
  • SSQTL1
  • TRP12
  • VRL2
  • VROAC
  • 0610033B08Rik
  • Trp12
  • VR-OAC
  • VRL-2
  • Otrpc4
  • Vroac
  • transient receptor potential cation channel, subfamily V, member 4
  • transient receptor potential cation channel subfamily V member 4
  • trpv4
  • TRPV4
  • Trpv4
Epitope
1st Cytoplasmic Loop
16
14
8
6
4
3
3
3
3
2
2
2
2
2
2
1
1
1
1
Reactivity
Chicken
107
65
63
7
7
6
4
2
2
2
2
1
1
Host
Rabbit
109
6
1
Clonality
Polyclonal
Conjugate
This TRPV4 antibody is un-conjugated
4
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
82
41
39
14
13
6
2
1
1
Options
Immunogen A synthetic peptide from the 1t cytoplasmic loop of chicken TRPV4 conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for TRPV4.
Purification Whole serum
Plasmids, Primers & others Plasmids, Primers & others TRPV4 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name TRPV4 (TRPV4 Antibody Abstract)
Background Function: Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism.
Subunit: Homotetramer. Self-associates in a isoform-specific manner. Isoforms 1/A and 5/D but not isoform 2/B, 4/C and 6/E can oligomerize. Interacts with calmodulin. Interacts with Map7 and Src family Tyr protein kinases LYN, SRC, FYN, HCK, LCK and YES.
Subcellular location: Membrane, Multi-pass membrane protein. Note: Assembly of the putative homotetramer occurs primarily in the endoplasmic reticulum. Also known as: Osm-9-like TRP channel 4, OTRPC4, Vanilloid receptor-like channel 2, Vanilloid receptor-like protein 2, VRL-2, Vanilloid receptor-related osmotically-activated channel, VR-OAC, Transient receptor potential protein 12, TRP12, Transient receptor potential cation channel subfamily V member 4, VRL2, VROAC.
Pathways Hormone Transport, Cell-Cell Junction Organization
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Liedtke, Choe, Martí-Renom, Bell, Denis, Sali, Hudspeth, Friedman, Heller: "Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor." in: Cell, Vol. 103, Issue 3, pp. 525-35, 2000 (PubMed).

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