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Contactin 1 antibody (CNTN1) Primary Antibody

CNTN1 Reactivity: Mouse IHC, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN350242
$454.67
Plus shipping costs $45.00
100 μL
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Delivery in 7 to 8 Business Days
  • Target
    Contactin 1 (CNTN1)
    Reactivity
    • 45
    • 29
    • 18
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    Mouse
    Host
    • 41
    • 10
    • 2
    • 2
    Rabbit
    Clonality
    • 45
    • 10
    Polyclonal
    Conjugate
    • 24
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Contactin 1 antibody is un-conjugated
    Application
    • 43
    • 26
    • 18
    • 11
    • 9
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Western Blotting (WB)
    Specificity
    Specific for contactin-1.
    Purification
    Whole serum
    Immunogen
    A synthetic peptide from mouse Contactin-1 (contactin 1, CNTN1) conjugated to an immunogenic carrier protein was used as the antigen.
  • Application Notes
    A dilution of 1 : 300 to 1 : 2000 is recommended.
    The optimal dilution should be determined by the end user.
    Not yet tested in other applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
    Handling Advice
    Avoid freeze and thaw cycles.
    Storage
    4 °C/-20 °C
    Storage Comment
    Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
    Expiry Date
    12 months
  • Target
    Contactin 1 (CNTN1)
    Alternative Name
    Contactin 1 (CNTN1 Antibody Abstract)
    Synonyms
    F3, GP135, AW495098, CNTN, F3cam, F3/F11, cntn-A, F11, CNTN1, cntn1, contactin 1, contactin 1 L homeolog, contactin 1a, CNTN1, Cntn1, cntn1.L, cntn1a
    Background
    Function:Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth.
    Subunit: Monomer. Interacts with CNTNAP1 in cis form. Binds to the carbonic-anhydrase like domain of protein-tyrosine phosphatase zeta. Interacts with NOTCH1 and TNR.
    Subcellular location: Cell membrane, Lipid-anchor, GPI-anchor.
    Miscellaneous: F3 shares with L1, N-CAM, MAG, and other cell adhesion molecules from nervous tissue the L2/HNK-1 carbohydrate epitope. Also known as: Neural cell surface protein F3, F3cam,Contactin 1, CNTN1.
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