A synthetic peptide from the n-terminal of mouse DRAM conjugated to an immunogenic carrier protein has been used as the antigen. The peptide is homologous in rat and shares 86% identity with human's.
DRAM1
Reactivity: Human
WB, ELISA
Host: Rabbit
Polyclonal
unconjugated
Application Notes
IHC, WB. Use at a concentration of 10-50 μg,ml. The optimal concentration should be determined by the end user. Not yet tested in other applications.
Restrictions
For Research Use only
Format
Lyophilized
Reconstitution
Reconstitute in 500 μL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice
Avoid freeze and thaw cycles.
Storage
4 °C/-20 °C
Storage Comment
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months
Target
DRAM (DRAM1)
(DNA-Damage Regulated Autophagy Modulator 1 (DRAM1))
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Background
This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. FUNCTION: Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy. SUBCELLULAR LOCATION: Lysosome membrane, Multi-pass membrane protein.,Mammalian Autophagy,Damage-regulated autophagy modulator