Microtubule-Associated Protein 1 Light Chain 3 beta (MAP1LC3B) antibody

Details for Product No. ABIN350465
Antigen
  • ATG8F
  • LC3B
  • MAP1A/1BLC3
  • MAP1LC3B-a
  • Map1lc3
  • Mpl3
  • zbs559
  • 1010001C15Rik
  • Atg8
  • LC3b
  • zgc:56434
  • wu:fb60g11
  • map1lc3b
  • MGC76283
  • MAP1LC3B
  • microtubule associated protein 1 light chain 3 beta
  • microtubule-associated protein 1 light chain 3 beta
  • microtubule associated protein 1 light chain 3 beta L homeolog
  • MAP1LC3B
  • Map1lc3b
  • map1lc3b
  • map1lc3b.L
Reactivity
Rat (Rattus), Mouse (Murine)
257
123
97
5
5
4
2
2
2
1
Host
Rabbit
231
27
7
1
Clonality
Polyclonal
Conjugate
Un-conjugated
16
15
13
13
13
11
4
4
4
4
3
3
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
137
128
75
73
45
25
24
10
10
7
7
6
4
3
1
1
Options
Immunogen A synthetic peptide from mouse LC3 B conjugated to blue carrier protein has been used as the antigen. The peptide is homologous in rat.
Specificity Specific for MAP1LC3B.
Purification Whole serum
Antigen
Alternative Name LC3 B (MAP1LC3B Antibody Abstract)
Background Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly.autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels ofautophagy have been described in some malignant tumors, and a role forautophagy in controlling the unregulated cell growth linked to cancer has been proposed.
Function: Probably involved in formation of autophagosomal vacuoles (autophagosomes). May mediate MAPlA and MAPlB microtubule binding activity during development of the nervous system
Subunit: 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins.
Subcellular location: Cytoplasm. Intracytoplasmic membrane, Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane, Lipid-anchor.Note: LC3-II binds to the autophagic membranes. Also known as: MLP3B, Map1alc3, Map1lc3, Microtubule-associated protein 1 light chain 3 beta, MAP1A/MAP1B LC3 B, MAP1A/1B light chain 3 B, MAP1 light chain 3-like protein 2,autophagy-related protein LC3 B,autophagy-related ubiquitin-like modifier LC3 B, Mpl3, MGC93422.
Pathways Autophagy
Application Notes Use at a dilution of 1 : 300 to 1 : 2000.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Seidenbecher, Landwehr, Smalla, Kreutz, Dieterich, Zuschratter, Reissner, Hammarback, Boeckers, Gundelfinger, Kreutz: "Caldendrin but not calmodulin binds to light chain 3 of MAP1A/B: an association with the microtubule cytoskeleton highlighting exclusive binding partners for neuronal Ca(2+)-sensor proteins." in: Journal of molecular biology, Vol. 336, Issue 4, pp. 957-70, 2004 (PubMed).

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