PKD2L1 antibody (Polycystic Kidney Disease 2-Like 1) (1st Cytoplasmic Loop)

Catalog No. ABIN350746

Product Details anti-PKD2L1 Antibody

Target:

PKD2L1

Binding Specificity: 1st Cytoplasmic Loop

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PKD2L1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Specificity: Specific for PKD2L1.

Purification: Whole serum

Immunogen: A synthetic peptide from the 1t cytoplasmic loop of human PK2L1 conjugated to blue carrier protein was used as the antigen.

Application Details

Application Notes: A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

Handling Advice: Avoid freeze and thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date: 12 months

Target Details for PKD2L1

Target:

PKD2L1

Alternative Name: PKD2L1 (PKD2L1 Antibody Abstract)

Background: This gene encodes a member of the polycystin protein family. The encoded protein contains multipletransmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. This protein functions as a calcium-regulated nonselective cation channel. Alternative splice variants have been described but their full length sequences have not been determined
Function: May function as a subunit of an ion channel and act as a transducer of calcium-mediated signaling.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Expressed in adult heart, skeletal muscle, brain, spleen, testis, retina and liver. According to Ref.1 expressed at high levels in fetal tissues, including kidney and liver, and down-regulated in adult tissues. It has been found to be expressed in fetal brain, but not expressed in fetal lung, liver or kidney. Isoform 4 appears to be expressed only in transformed lymphoblasts. Also known as: PK2L1, PKD2L1, PKD2L, PKDL, Polycystin-L.