Pyx antibody (AA 400-450)

Catalog No. ABIN350776

Product Details anti-Pyx Antibody

Target: Pyx (pyx)

Binding Specificity: AA 400-450

Reactivity: Drosophila melanogaster

Host: Rabbit

Clonality: Polyclonal

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Specificity: Specific for PYX.

Cross-Reactivity: Drosophila melanogaster

Cross-Reactivity (Details): Other species not yet tested.

Purification: Whole serum

Immunogen: A synthetic peptide from AA 400-450 of drosophila PYX conjugated to blue carrier protein was used as the antigen.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute in 100 μL of sterile water. Centrifuge to remove any insoluble material.

Handling Advice: Avoid freeze and thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date: 12 months

Target Details for Pyx

Target: Pyx (pyx)

Alternative Name: PYX

Synonyms: CG17142 antibody, CT33412 antibody, Dmel\\CG17142 antibody, Pyx antibody, pyrexia antibody, pyx antibody

Background: FUNCTION: Receptor-activated non-selective cation channel involved in protection or tolerance from high temperature stress. Activated by temperatures above 40 degrees Celsius. More permeable to K(+) than to Na(+). May act in stress protection allow flies to survive in natural environments. SUBUNIT: Homooligomer, between isoform A and isoform B. SUBCELLULAR LOCATION: Membrane, Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in various peripheral nerves and the central nerves in embryos. In adults, it is expressed in sensory neurons lying beneath the bristles around eyes, neurons innervating the bristles on the back of thorax and neurons in maxillary palps, proboscis and antennae. Expressed in multidendritic neurons, which mediate temperature sensing, as well as non-multidendritic neurons in larval epidermis. Localizes ubiquitously throughout neurites.,Drosophila TRP,Transient receptor potential channel pyrexia

UniProt: Q9W0T5