TRPV1 antibody (1st Cytoplasmic Loop)

Catalog No. ABIN351259

Product Details anti-TRPV1 Antibody

Target: TRPV1 (Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1))

Binding Specificity: 1st Cytoplasmic Loop

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRPV1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificity: Specific for TRPV1.

Immunogen: A synthetic peptide from the 1t cytoplasmic loop of mouse TRPV1 (VR1, capsaicin receptor, vanilloid receptor 1) conjugated to an immunogenic carrier protein was used as the immunogen.

Isotype: IgG

Application Details

Application Notes: A concentration of 10-50 µg/ml recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

Handling Advice: Avoid freeze and thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date: 12 months

Target Details for TRPV1

Target: TRPV1 (Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1))

Alternative Name: TRPV1 (TRPV1 Products)

Synonyms: si:dkey-9e15.2 antibody, VR.5'sv antibody, Vr1 antibody, Vr1l1 antibody, VR1 antibody, OTRPC1 antibody, TRPV1alpha antibody, TRPV1beta antibody, VR-1 antibody, transient receptor potential cation channel, subfamily V, member 1 antibody, transient receptor potential cation channel subfamily V member 1 antibody, trpv1 antibody, Trpv1 antibody, TRPV1 antibody

Background: Function: Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH Also known as: Transient receptor potential cation channel subfamily V member 1, TrpV1, osm-9-like TRP channel 1, OTRPC1, Vanilloid receptor 1, Vanilloid receptor type 1-like, Capsaicin receptor, transient receptor potential cation channel, subfamily V, member 1, Vr1, Vr1l1, VR.5'sv.

Pathways: Dicarboxylic Acid Transport