TRPV4 antibody (Transient Receptor Potential Cation Channel, Subfamily V, Member 4) (1st Cytoplasmic Domain)

Details for Product anti-TRPV4 Antibody No. ABIN351280
Antigen
Epitope
1st Cytoplasmic Domain
17
15
9
7
4
3
3
3
2
2
2
2
2
2
2
1
1
1
1
Reactivity
Mouse (Murine)
108
64
63
7
7
6
4
3
2
2
2
1
1
Host
Rabbit
110
6
1
Clonality
Polyclonal
Conjugate
This TRPV4 antibody is un-conjugated
4
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
85
42
39
14
13
6
2
1
1
1
Options
Immunogen A synthetic peptide from 1t cytoplasmic domain of mouse TRPV4 conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for TRPV4.
Purification Whole serum
Antigen
Alternative Name TRPV4 (TRPV4 Antibody Abstract)
Background TRPV4 is a cation-selective channel, activated in response to systemic osmotic pressure.
Function: Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism.
Subunit: Interacts with calmodulin. Interacts with Map7 and Src family Tyr protein kinases LYN, SRC, FYN, HCK, LCK and YES.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Expressed lung, spleen, kidney, testis, fat, and at very low levels in trigeminal ganglia. Also known as: Transient receptor potential cation channel subfamily V member 4, TrpV4, osm-9-like TRP channel 4, OTRPC4, Vanilloid receptor-like channel 2, Vanilloid receptor-like protein 2, Vanilloid receptor-related osmotically-activated channel, VR-OAC, Transient receptor potential protein 12, TRP12, Trp12, VRL-2, VROAC, OTRPC4, VR-OAC, MGC150050, 0610033B08Rik, Trp12, Vrl2, Vroac.
Pathways Hormone Transport, Cell-Cell Junction Organization
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months