TRPV4 antibody (Transient Receptor Potential Cation Channel, Subfamily V, Member 4) (4th Cytoplasmic Loop)

Details for Product anti-TRPV4 Antibody No. ABIN351288
Antigen
  • wu:fp52e02
  • CMT2C
  • HMSN2C
  • OTRPC4
  • SMAL
  • SPSMA
  • SSQTL1
  • TRP12
  • VRL2
  • VROAC
  • 0610033B08Rik
  • Trp12
  • VR-OAC
  • VRL-2
  • Otrpc4
  • Vroac
  • transient receptor potential cation channel, subfamily V, member 4
  • transient receptor potential cation channel subfamily V member 4
  • trpv4
  • TRPV4
  • Trpv4
Epitope
4th Cytoplasmic Loop
16
14
8
7
4
3
3
3
3
2
2
2
2
2
1
1
1
1
1
Reactivity
Rat (Rattus)
107
65
62
7
7
6
4
3
2
2
2
1
1
Host
Rabbit
109
6
1
Clonality
Polyclonal
Conjugate
This TRPV4 antibody is un-conjugated
4
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
82
41
39
14
13
6
2
1
1
Options
Immunogen A synthetic peptide from the 4th cytoplasmic loop of rat TRPV4 (VRL-2, VRL2) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Specific for TRPV4.
Purification Whole serum
Plasmids, Primers & others Plasmids, Primers & others TRPV4 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name TRPV4 (TRPV4 Antibody Abstract)
Background TRPV4 is a cation-selective channel, activated in response to systemic osmotic pressure.
Function: Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism.
Subunit: Interacts with calmodulin. Interacts with Map7 and Src family Tyr protein kinases LYN, SRC, FYN, HCK, LCK and YES.
Subcellular location: Membrane, Multi-pass membrane protein
Tissue specificity: Expressed lung, spleen, kidney, testis, fat, and at very low levels in trigeminal ganglia. SIMILARITY: Belongs to the transient receptor family, TrpV subfamily. SIMILARITY: Contains 3 ANK repeats. Also known as: Transient receptor potential cation channel subfamily V member 4, TrpV4, osm-9-like TRP channel 4, OTRPC4, Vanilloid receptor-related, smotically-activated channel, VR-OAC, Vroac, Otrpc4.
Pathways Hormone Transport, Cell-Cell Junction Organization
Application Notes A dilution of 1: 300 to 1: 3000 is recommended.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Supplier Images
Image no. 1 for anti-Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4) (4th Cytoplasmic Loop) antibody (ABIN351288) IHC on paraffin sections of rat kidney tissue using Rabbit antibody to TRPV4: .HIER: ...
Image no. 2 for anti-Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4) (4th Cytoplasmic Loop) antibody (ABIN351288) IHC on paraffin sections of rat kidney tissue using Rabbit antibody to TRPV4: .HIER: ...
Image no. 3 for anti-Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4) (4th Cytoplasmic Loop) antibody (ABIN351288) IHC on paraffin sections of rat kidney tissue using Rabbit antibody to TRPV4: .HIER: ...
Image no. 4 for anti-Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4) (4th Cytoplasmic Loop) antibody (ABIN351288) IHC on paraffin sections of rat testis tissue using Rabbit antibody to TRPV4: .HIER: ...
Image no. 5 for anti-Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4) (4th Cytoplasmic Loop) antibody (ABIN351288) IHC on paraffin sections of rat testis tissue using Rabbit antibody to TRPV4: .HIER: ...
Image no. 6 for anti-Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4) (4th Cytoplasmic Loop) antibody (ABIN351288) IHC on paraffin sections of rat kidney tissue using Rabbit antibody to TRPV4: .HIER: ...
Image no. 7 for anti-Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4) (4th Cytoplasmic Loop) antibody (ABIN351288) IHC on paraffin sections of rat kidney tissue using Rabbit antibody to TRPV4: .HIER: ...
Background publications Marrelli, Oneil, Brown, Bryan: "PLA2 and TRPV4 channels regulate endothelial calcium in cerebral arteries." in: American journal of physiology. Heart and circulatory physiology, Vol. 292, Issue 3, pp. H1390-7, 2007 (PubMed).

Koehler, Heyken, Heinau, Schubert, Si, Kacik, Busch, Grgic, Maier, Hoyer: "Evidence for a functional role of endothelial transient receptor potential V4 in shear stress-induced vasodilatation." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 26, Issue 7, pp. 1495-502, 2006 (PubMed).

Tsushima, Mori: "Antidipsogenic effects of a TRPV4 agonist, 4alpha-phorbol 12,13-didecanoate, injected into the cerebroventricle." in: American journal of physiology. Regulatory, integrative and comparative physiology, Vol. 290, Issue 6, pp. R1736-41, 2006 (PubMed).

Earley, Heppner, Nelson, Brayden: "TRPV4 forms a novel Ca2+ signaling complex with ryanodine receptors and BKCa channels." in: Circulation research, Vol. 97, Issue 12, pp. 1270-9, 2005 (PubMed).

Liedtke, Tobin, Bargmann, Friedman: "Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100 Suppl 2, pp. 14531-6, 2003 (PubMed).

Liedtke, Choe, Martí-Renom, Bell, Denis, Sali, Hudspeth, Friedman, Heller: "Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor." in: Cell, Vol. 103, Issue 3, pp. 525-35, 2000 (PubMed).

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