Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

PRKAR2B antibody (N-Term)

PRKAR2B Reactivity: Human, Mouse WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN359121
  • Target See all PRKAR2B Antibodies
    PRKAR2B (Protein Kinase, CAMP-Dependent, Regulatory, Type II, beta (PRKAR2B))
    Binding Specificity
    • 8
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 56
    • 27
    • 18
    • 1
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 54
    • 2
    Rabbit
    Clonality
    • 53
    • 3
    Polyclonal
    Conjugate
    • 29
    • 5
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PRKAR2B antibody is un-conjugated
    Application
    • 47
    • 38
    • 10
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificity
    This antibody reacts to PKA 2 beta (PRKAR2B).
    Purification
    Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
    Immunogen
    This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human PRKAR2B.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product PRKAR2B Primary Antibody
  • Application Notes
    ELISA: 1/1,000. Western blotting: 1/100- 1/500. Flow cytometry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS with 0.09 % (W/V) sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Target
    PRKAR2B (Protein Kinase, CAMP-Dependent, Regulatory, Type II, beta (PRKAR2B))
    Alternative Name
    PRKAR2B (PRKAR2B Products)
    Synonyms
    MGC83177 antibody, PRKAR2B antibody, AI451071 antibody, AW061005 antibody, PKARIIbeta antibody, Pkarb2 antibody, RII(beta) antibody, RATDNA antibody, PRKAR2 antibody, RII-BETA antibody, protein kinase, cAMP-dependent, regulatory subunit type II beta S homeolog antibody, protein kinase cAMP-dependent type II regulatory subunit beta antibody, protein kinase, cAMP-dependent, regulatory, type II, beta antibody, protein kinase, cAMP dependent regulatory, type II beta antibody, protein kinase cAMP-dependent type 2 regulatory subunit beta antibody, prkar2b.S antibody, PRKAR2B antibody, prkar2b antibody, Prkar2b antibody
    Background
    CAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol.Synonyms: PRKAR2, cAMP-dependent protein kinase type II-beta regulatory subunit
    Gene ID
    5577, 5874
    UniProt
    P31323
    Pathways
    Hedgehog Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Myometrial Relaxation and Contraction, M Phase, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
You are here:
Support