GABRG2 antibody (gamma-aminobutyric Acid (GABA) A Receptor, gamma 2)

Details for Product anti-GABRG2 Antibody No. ABIN361438
Target
Reactivity
Rat
69
54
52
13
11
6
6
6
5
5
3
3
3
2
Host
Rabbit
68
9
1
Clonality
Polyclonal
Conjugate
This GABRG2 antibody is un-conjugated
5
4
4
3
3
3
2
2
2
2
2
2
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
60
31
21
14
6
4
2
2
1
1
1
Options
Immunogen Synthetic peptide corresponding to amino acid residues specific to the gamma 2 subunit conjugated to KLH
Specificity Specific for the ~46k 2-subunit of the GABAA receptor in Western blots of rat brain extracts.
Cross-Reactivity Rat (Rattus)
Predicted Reactivity chicken, human, mouse, non-human primate, zebra fish
Purification Neat Pooled Serum
Target
Alternative Name GABRG2 (GABRG2 Antibody Abstract)
Background Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six (s, four (s and four (s, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990, Whiting et al., 1999, Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for (- and (-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, co-expression of a (-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different (-subunits of the receptor (McKernan et al., 2000, Mehta and Ticku, 1998, Ogris et al., 2004, Pöltl et al., 2003). Lastly, phosphorylation of (-subunits of the receptor has been shown to modulate GABAA-R function (Brandon et al., 2003). Anti-GABAA Receptor, (2-Subunit Western blot of 10 (g of rat hippocampal lysate showing immunolabeling of the ~46k (2-subunit of the GABAA-R.
Molecular Weight '46 kDa
Gene ID 29709
UniProt P18508
Application Notes Recommended Dilution: WB: 1:1000 IHC: 1:400 Quality Control: Western blots performed on each lot.
Restrictions For Research Use only
Format Liquid
Buffer neat serum
Storage -20 °C
Images
Image no. 1 for anti-gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2) antibody (ABIN361438) Western blots of 10 (g of rat hippocampal lysate showing immunolabeling of the ~46k (...