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GABRA6 antibody (Cytoplasmic Loop)

GABRA6 Reactivity: Rat WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN361444
  • Target See all GABRA6 Antibodies
    GABRA6 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6))
    Binding Specificity
    • 15
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cytoplasmic Loop
    Reactivity
    • 42
    • 25
    • 22
    • 7
    • 4
    • 4
    • 1
    Rat
    Host
    • 46
    • 1
    Rabbit
    Clonality
    • 47
    Polyclonal
    Conjugate
    • 17
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GABRA6 antibody is un-conjugated
    Application
    • 34
    • 13
    • 13
    • 12
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Specificity
    Specific for the ~57k a6-subunit of the GABAA receptor in Western blots. Labeling is absent in a6-subunit knockout animals.
    Cross-Reactivity
    Mouse (Murine), Rat (Rattus)
    Purification
    Antigen Affinity Purified
    Immunogen
    Fusion protein from the cytoplasmic loop of the alpha 6 subunit
    Top Product
    Discover our top product GABRA6 Primary Antibody
  • Application Notes
    Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
    Storage
    -20 °C
  • Target
    GABRA6 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6))
    Alternative Name
    GABRA6 (GABRA6 Products)
    Synonyms
    LOC100224835 antibody, GABRA6 antibody, Gabra-6 antibody, alpha6 antibody, si:dkey-217k23.1 antibody, zgc:73148 antibody, gamma-aminobutyric acid type A receptor alpha 6 subunit antibody, gamma-aminobutyric acid type A receptor alpha6 subunit antibody, gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6 antibody, gamma-aminobutyric acid (GABA) A receptor, alpha 6a antibody, Gabra6 antibody, GABRA6 antibody, gabra6a antibody
    Background
    Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six (s, four (s and four (s, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990, Whiting et al., 1999, Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for (- and (-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a (-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different (-subunits of the receptor (McKernan et al., 2000, Mehta and Ticku, 1998, Ogris et al., 2004, P ltl et al., 2003). Anti-GABAA Receptor, a6-Subunit Western blot of mouse forebrain lysates from Wild Type (Control) and 6-knockout (6-K/O) animals showing specific immunolabeling of the ~57k a6-subunit of the GABAA-R. The labeling was absent from a lysate prepared from 6-knockout animals.
    Molecular Weight
    '57 kDa
    Gene ID
    29708
    UniProt
    P30191
    Pathways
    Synaptic Membrane
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