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GABRB2 antibody (Cytoplasmic Loop)

GABRB2 Reactivity: Rat WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN361447
  • Target See all GABRB2 Antibodies
    GABRB2 (gamma-aminobutyric Acid (GABA) A Receptor, beta 2 (GABRB2))
    Binding Specificity
    • 15
    • 15
    • 10
    • 8
    • 6
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cytoplasmic Loop
    Reactivity
    • 59
    • 54
    • 36
    • 12
    • 9
    • 8
    • 8
    • 6
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Rat
    Host
    • 77
    • 1
    Rabbit
    Clonality
    • 77
    • 1
    Polyclonal
    Conjugate
    • 31
    • 6
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    This GABRB2 antibody is un-conjugated
    Application
    • 68
    • 29
    • 26
    • 26
    • 9
    • 7
    • 6
    • 3
    • 3
    • 1
    Western Blotting (WB)
    Specificity
    Specific for the ~55k ß2-subunit of the GABAA receptor in Western blots.
    Cross-Reactivity
    Mouse (Murine), Rat (Rattus)
    Predicted Reactivity
    canine, human, non-human primate
    Purification
    Antigen Affinity Purified
    Immunogen
    Fusion protein from the cytoplasmic loop of the beta 2 subunit
  • Application Notes
    Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
    Storage
    -20 °C
  • Antflick, Hampson: "Modulation of glutamate release from parallel fibers by mGlu4 and pre-synaptic GABA(A) receptors." in: Journal of neurochemistry, Vol. 120, Issue 4, pp. 552-63, (2012) (PubMed).

  • Target
    GABRB2 (gamma-aminobutyric Acid (GABA) A Receptor, beta 2 (GABRB2))
    Alternative Name
    GABRB2 (GABRB2 Products)
    Synonyms
    GABRB2 antibody, GARB2 antibody, fj59e04 antibody, gabaabeta2 antibody, wu:fj59e04 antibody, zgc:136311 antibody, GABARB antibody, AI834970 antibody, C030002O17Rik antibody, C030021G16Rik antibody, Gabrab2 antibody, Gabrb-2 antibody, gamma-aminobutyric acid type A receptor beta2 subunit antibody, gamma-aminobutyric acid (GABA) A receptor, beta 2 antibody, gamma-aminobutyric acid type A receptor beta 2 subunit antibody, gamma-aminobutyric acid (GABA) A receptor, subunit beta 2 antibody, GABRB2 antibody, gabrb2 antibody, Gabrb2 antibody
    Background
    Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six (s, four (s and four (s, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990, Whiting et al., 1999, Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for (- and (-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a (-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different (-subunits of the receptor (McKernan et al., 2000, Mehta and Ticku, 1998, Ogris et al., 2004, Pöltl et al., 2003). Anti-GABAA-Receptor, (2-Subunit Western blot of 7 (g of rat cerebellum (Cb) showing specific immunolabeling of the ~55k ß2-subunit of the GABAA-R.
    Molecular Weight
    '55 kDa
    Gene ID
    25451
    UniProt
    P63138
    Pathways
    Sensory Perception of Sound, Synaptic Membrane
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