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STXBP2 antibody (pSer513)

STXBP2 Reactivity: Rat WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN361480
  • Target See all STXBP2 Antibodies
    STXBP2 (Syntaxin Binding Protein 2 (STXBP2))
    Binding Specificity
    • 8
    • 8
    • 7
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer513
    Reactivity
    • 39
    • 9
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Rat
    Host
    • 38
    • 1
    • 1
    Rabbit
    Clonality
    • 39
    • 1
    Polyclonal
    Conjugate
    • 23
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This STXBP2 antibody is un-conjugated
    Application
    • 31
    • 19
    • 7
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Specificity
    Specific for the ~65k Munc-18 protein phosphorylated at Ser515. Immunolabeling is blocked by the phosphopeptide used as antigen but not by the corresponding dephosphopeptide.
    Cross-Reactivity
    Rat (Rattus)
    Predicted Reactivity
    bovine, canine, chicken, human, mouse, non-human primate, Xenopus
    Purification
    Antigen Affinity Purified from Pooled Serum
    Immunogen
    Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser513 conjugated to KLH
  • Application Notes
    Recommended Dilution: WB: 1:1000 IHC: 1:400 Quality Control: Western blots performed on each lot.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
    Storage
    -20 °C
  • Target
    STXBP2 (Syntaxin Binding Protein 2 (STXBP2))
    Alternative Name
    STXBP2 (STXBP2 Products)
    Synonyms
    zgc:85807 antibody, FHL5 antibody, Hunc18b antibody, MUNC18-2 antibody, UNC18-2 antibody, UNC18B antibody, pp10122 antibody, C79054 antibody, Munc-18-2 antibody, Munc-18b antibody, Munc18b antibody, Sxtbp2 antibody, Sxtp2 antibody, Unc18-2 antibody, Unc18b antibody, muSec1 antibody, MUNC-18-2 antibody, syntaxin binding protein 2 antibody, stxbp2 antibody, STXBP2 antibody, Stxbp2 antibody
    Background
    Munc-18 ( mammalian homologue of Unc-18) is a protein that is thought to be involved in regulating exocytosis due, at least in part, to it ability to bind syntaxin (Ciufo et al., 2005). Munc18-1 is a neuron-specific member of the Sec1/Munc18 protein family that binds to syntaxin1A and is thought to stabilize the complex (Liu et al., 2004). The function of Munc-18 is thought to be regulated by PKC phosphorylation of Ser515 on the Munc-18 protein (Sassa et al., 1996). Anti-Phospho-Ser515 Munc-18 Western blot of rat cortex lysate showing specific immunolabeling of the ~65k Munc-18 protein phosphorylated at Ser515. Immunolabeling is blocked by the phosphopeptide (peptide) used as antigen but not by the corresponding dephosphopeptide (not shown). .
    Molecular Weight
    '65 kDa
    Gene ID
    81804
    UniProt
    Q62753
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Synaptic Vesicle Exocytosis
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