KCNC1 antibody (pSer503)

Catalog No. ABIN361488

Product Details anti-KCNC1 Antibody

Target: KCNC1 (Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 1 (KCNC1))

Binding Specificity: pSer503

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNC1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificity: Specific for the ~100k Kv3.1 voltage-gated potassium channel protein phosphorylated at Ser503.

Cross-Reactivity: Mouse (Murine), Rat (Rattus)

Purification: Antigen Affinity Purified from Pooled Serum

Immunogen: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser503 conjugated to KLH

Application Details

Application Notes: Recommended Dilution: WB: 1:1000 IHC (frozen sections, unpublished observations): 1:1000 Quality Control: Western blots performed on each lot.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Storage: -20 °C

References for anti-KCNC1 antibody (ABIN361488)

Sagi, Medrihan, George, Barney, McCabe, Greengard: "Emergence of 5-HT5A signaling in parvalbumin neurons mediates delayed antidepressant action." in: Molecular psychiatry, Vol. 25, Issue 6, pp. 1191-1201, (2020) (PubMed).

Target Details for KCNC1

Target: KCNC1 (Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 1 (KCNC1))

Alternative Name: KCNC1 (KCNC1 Products)

Synonyms: kv3.1 antibody, C230009H10Rik antibody, KShIIIB antibody, KV4 antibody, Kcr2-1 antibody, Kv3.1 antibody, NGK2 antibody, Shaw antibody, Kv4 antibody, NGK2-KV4 antibody, KV3.1 antibody, KCNC2 antibody, zgc:194940 antibody, zgc:194950 antibody, potassium voltage-gated channel subfamily C member 1 antibody, potassium voltage-gated channel, Shaw-related subfamily, member 1 antibody, potassium voltage gated channel, Shaw-related subfamily, member 1 antibody, potassium voltage-gated channel, Shaw-related subfamily, member 1a antibody, KCNC1 antibody, kcnc1 antibody, Kcnc1 antibody, kcnc1a antibody

Background: Voltage-gated K+ channels are important determinants of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types (Maletic-Savatic et al., 1995, Pongs, 1999, Blaine and Ribera, 1998, Burger and Ribera, 1996). The Kv3.1 potassium channel is expressed at high levels in neurons that characteristically fire rapid trains of action potentials (Gan et al., 1999). Particularly high levels of this channel are found in neurons of the auditory brainstem. These neurons appear to participate in neural circuits that determine the intensity and timing of auditory stimuli and use this information to determine the location of sounds in space (von Hehn et al., 2004).

Molecular Weight: '100 kDa

Gene ID: 25327

UniProt: P25122