Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

SOD2 antibody

SOD2 Reactivity: Human WB, IHC, ELISA, IP Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN361648
  • Target See all SOD2 Antibodies
    SOD2 (Superoxide Dismutase 2, Mitochondrial (SOD2))
    Reactivity
    • 127
    • 91
    • 81
    • 30
    • 28
    • 27
    • 26
    • 26
    • 25
    • 25
    • 23
    • 22
    • 20
    • 12
    • 10
    • 10
    • 10
    • 10
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 130
    • 21
    • 5
    • 1
    Rabbit
    Clonality
    • 129
    • 27
    Polyclonal
    Conjugate
    • 61
    • 17
    • 15
    • 8
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This SOD2 antibody is un-conjugated
    Application
    • 146
    • 82
    • 73
    • 50
    • 25
    • 21
    • 18
    • 16
    • 13
    • 13
    • 7
    • 5
    • 5
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP)
    Specificity
    Detects ~25 kDa.
    Cross-Reactivity
    Chicken, Cow, Dog, Frog, Gerbil, Guinea Pig, Hamster, Human, Monkey, Mouse, Pig, Rabbit, Rat, Sheep, Xenopus laevis
    Purification
    Protein A Purified
    Immunogen
    Recombinant Human Mn SOD Protein
    Top Product
    Discover our top product SOD2 Primary Antibody
  • Application Notes
    • WB (1:5000)
    • IHC (1:100)
    • optimal dilutions for assays should be determined by the user.
    Comment

    0.2 μg/ml of ABIN361647 was sufficient for detection of Mn SOD in 20 μg of rat brain tissue extract by colorimetric immunoblot analysis using Goat anti-mouse IgG:AP as the secondary antibody.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    -20°C
  • Dawson, Katzenback, Storey: "Free-radical first responders: the characterization of CuZnSOD and MnSOD regulation during freezing of the freeze-tolerant North American wood frog, Rana sylvatica." in: Biochimica et biophysica acta, Vol. 1850, Issue 1, pp. 97-106, (2014) (PubMed).

    Allan, Storey: "Expression of NF-?B and downstream antioxidant genes in skeletal muscle of hibernating ground squirrels, Spermophilus tridecemlineatus." in: Cell biochemistry and function, Vol. 30, Issue 2, pp. 166-74, (2012) (PubMed).

    Ishii, Kunihiro, Tanaka, Hatano, Nishikata: "Cytosolic subunits of ATP synthase are localized to the cortical endoplasmic reticulum-rich domain of the ascidian egg myoplasm." in: Development, growth & differentiation, Vol. 54, Issue 8, pp. 753-66, (2012) (PubMed).

  • Target
    SOD2 (Superoxide Dismutase 2, Mitochondrial (SOD2))
    Alternative Name
    SOD2 (SOD2 Products)
    Synonyms
    LOC100101896 antibody, MNSOD antibody, GB14346 antibody, sod2 antibody, MGC88869 antibody, Sod2 antibody, CG8905 antibody, Dmel\\CG8905 antibody, Mito SOD antibody, Mn SOD antibody, Mn-SOD antibody, Mn-SOD2 antibody, MnSOD antibody, MnSODII antibody, Mn[2+]SOD antibody, SOD antibody, SOD-2 antibody, SOD2 antibody, Sod-2 antibody, dSOD2 antibody, mitSOD2 antibody, mnSOD antibody, IPOB antibody, MVCD6 antibody, cb463 antibody, wu:fj33b01 antibody, zgc:73051 antibody, MnSOD antibody, manganese superoxide dismutase antibody, superoxide dismutase 2, mitochondrial antibody, superoxide dismutase 2 antibody, Mn superoxide dismutase antibody, Superoxide dismutase 2 (Mn) antibody, superoxide dismutase 2 L homeolog antibody, BDBG_07234 antibody, LOC100101896 antibody, MNSOD antibody, Sod2 antibody, sod2 antibody, LbMnSOD4 antibody, SOD2 antibody, LOC100282741 antibody, SOD-2 antibody, sod2.L antibody
    Background
    Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body (3). It works by catalyzing the dismutation of the superoxide radical O2ˉ to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase (2,5). In general, SODs play a major role in antioxidant defense mechanisms (4). There are two main types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge (3). The second form (SOD2) is a manganese containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form (SOD3 or EC-SOD) is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDA and it exists only in the extra-cellular space (7). SOD3 can also be distinguished by its heparin-binding capacity (1).
    Gene ID
    6648
    NCBI Accession
    NP_000627
    UniProt
    P04179
    Pathways
    Sensory Perception of Sound, Transition Metal Ion Homeostasis, Negative Regulation of intrinsic apoptotic Signaling
You are here:
Support