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Myocyte Enhancer Factor 2A (MEF2A) (pThr319) antibody Primary Antibody

MEF2A Reactivity: Human, Mouse, Rat IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN361951
$207.90
Plus shipping costs $45.00
50 μL ABIN361951
50 μL ABIN361951
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  • Target
    Myocyte Enhancer Factor 2A (MEF2A)
    Binding Specificity
    • 23
    • 19
    • 14
    • 11
    • 10
    • 9
    • 8
    • 8
    • 6
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pThr319
    Reactivity
    • 134
    • 112
    • 91
    • 14
    • 11
    • 10
    • 9
    • 9
    • 9
    • 6
    • 6
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    Human, Mouse, Rat
    Host
    • 130
    • 6
    Rabbit
    Clonality
    • 122
    • 14
    Polyclonal
    Conjugate
    • 70
    • 9
    • 7
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Un-conjugated
    Application
    • 87
    • 53
    • 46
    • 28
    • 26
    • 26
    • 21
    • 12
    • 7
    • 6
    • 5
    • 3
    • 3
    • 2
    Immunofluorescence (IF)
    Specificity
    The antibody detects endogenous level of MEF2A only when phosphorylated at Thr319.
    Purification
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed bychromatography using non-phosphopeptide corresponding to the phosphorylation site.
    Immunogen
    Peptide sequence around phosphorylation site of pThr319 (V-T-T (p) -P-S) derived from Human MEF2A. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
    Isotype
    IgG
  • Application Notes
    Immunofluorescence: 1:100-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • Target
    Myocyte Enhancer Factor 2A (MEF2A)
    Alternative Name
    MEF2A (MEF2A Antibody Abstract)
    Synonyms
    ADCAD1, RSRFC4, RSRFC9, mef2, A430079H05Rik, mef2a, wu:fd19d02, adcad1, rsrfc4, rsrfc9, sl2, MEF2A, xmef2a, myocyte enhancer factor 2A, myocyte enhancer factor 2aa, myocyte enhancer factor 2a, myocyte-specific enhancer factor 2A, myocyte-specific enhancer factor 2a, putative, myocyte enhancer factor 2A L homeolog, MEF2A, Mef2a, mef2aa, EDI_092490, EDI_038250, Smp_161530, mef2a.L, mef2a, LOC539054
    Background
    The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. The myogenic basic helix-loop-helix proteins, including myoD (MIM 159970), myogenin (MIM 159980), MYF5 (MIM 159990), and MRF4 (MIM 159991) are one class of identified factors. A second family of DNA binding regulatory proteins is the myocyte-specific enhancer factor-2 (MEF2) family. Each of these proteins binds to the MEF2 target DNA sequence present in the regulatory regions of many, if not all, muscle-specific genes. The MEF2 genes are members of the MADS gene family (named for the yeast mating type-specific transcription factor MCM1, the plant homeotic genes 'agamous' and 'deficiens' and the human serum response factor SRF (MIM 600589)), a family that also includes several homeotic genes and other transcription factors, all of which share a conserved DNA-binding domain
    Molecular Weight
    54 kDa
    NCBI Accession
    NP_001124
    UniProt
    Q02078
    Pathways
    Neurotrophin Signaling Pathway, Activation of Innate immune Response, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Muscle Cell Differentiation, Toll-Like Receptors Cascades
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