Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

APEX1 antibody

APEX1 Reactivity: Human, Mouse, Rat, Rabbit WB, IHC, IF, ICC, IP, ChIP, Neut Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN363379
  • Target See all APEX1 Antibodies
    APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))
    Reactivity
    • 87
    • 37
    • 34
    • 8
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Rabbit
    Host
    • 70
    • 18
    • 2
    Rabbit
    Clonality
    • 72
    • 18
    Polyclonal
    Conjugate
    • 67
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This APEX1 antibody is un-conjugated
    Application
    • 83
    • 30
    • 29
    • 27
    • 19
    • 12
    • 7
    • 6
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunoprecipitation (IP), Chromatin Immunoprecipitation (ChIP), Neutralization (Neut)
    Specificity
    Reacts with human ~37 kDa APE-1 protein
    Cross-Reactivity
    Mouse (Murine), Rabbit, Rat (Rattus)
    Cross-Reactivity (Details)
    Cross reacts with proteins from mouse, rat and rabbit.
    Purification
    Antigen affinity purified
    Immunogen
    Affinity purified human Apurinic/Apyrimidinic Endonuclease (APE/ref-1) fusion protein
    Top Product
    Discover our top product APEX1 Primary Antibody
  • Application Notes

    Working dilution: Optimal dilution should be determined by the end user.
    The following are guidelines only :
    - IHC: 1/1 000 - WB : 1/1 000 - B/N: 50-200 Molar excess - ChIP: 1/10-1/500 - ICC/IF: 1/50-1/200 - IP: 7 μg/mL

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.5 mg/mL
    Buffer
    Tris-glycine, NaCl 150 mM buffer, Sodium azide 0.05 %
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C/-80 °C
    Storage Comment
    Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
  • Target
    APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))
    Alternative Name
    DNA-(Apurinic Or Apyrimidinic Site) Lyase (APE-1) (APEX1 Products)
    Synonyms
    apex1 antibody, MGC76280 antibody, MGC79645 antibody, MGC78928 antibody, APE antibody, APE1 antibody, APEN antibody, APEX antibody, APX antibody, HAP1 antibody, REF1 antibody, Apex antibody, REF-1 antibody, BAP1 antibody, apex1a antibody, hm:zehn1532 antibody, wu:fc13d11 antibody, zgc:66204 antibody, Ref-1 antibody, apurinic/apyrimidinic endodeoxyribonuclease 1 antibody, APEX nuclease (multifunctional DNA repair enzyme) 1 antibody, APEX nuclease (multifunctional DNA repair enzyme) 1 L homeolog antibody, DNA-(apurinic or apyrimidinic site) lyase antibody, apurinic/apyrimidinic endonuclease 1 antibody, APEX1 antibody, apex1 antibody, apex1.L antibody, CNG03640 antibody, CNH01280 antibody, nth antibody, Spirs_4119 antibody, Palpr_0103 antibody, Apex1 antibody
    Background
    Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents.
    Gene ID
    328
    Pathways
    DNA Damage Repair, Chromatin Binding, Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Positive Regulation of Response to DNA Damage Stimulus
You are here:
Support