Klra3
(Killer Cell Lectin-Like Receptor, Subfamily A, Member 3 (Klra3))
Reactivity
Mouse
Host
Hamster
Clonality
Monoclonal
Conjugate
This Klra3 antibody is un-conjugated
Application
Flow Cytometry (FACS)
Specificity
This antibody is specific to an epitope common to the Ly49C, Ly49F, Ly49H and Ly49I allelic/splice variants. The antibody stains ~ 90 % of NK1.1+CD3- splenocytes, and ~ 6 % of CD8+ spleen cells from C57BL/6 mice. (Ref.1) The antibody also stains 30-80 % of NK1.1+CD3-splenocytes in other mouse strains tested (BALB/c, C3H, 129, SJL, AKR/J).
Characteristics
Synonyms: Ly49C, Ly49F, Ly49H, Ly49I, Ly-49H, Ly-49C, Ly-49F, Ly-49I, Klra3, Klra9, Klra8, Klra6, T cellsurface glycoprotein Ly 49C, T cell surface glycoprotein Ly 49F, T cell surface glycoproteinLy 49H, T cell surface glycoprotein Ly 49I, Killer cell lectin-like receptor
Flow Cytometry: < / = 1 μg/10^6 cells. (Ref.1,3) Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Concentration
0.5 mg/mL
Buffer
100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Expiry Date
12 months
Target
Klra3
(Killer Cell Lectin-Like Receptor, Subfamily A, Member 3 (Klra3))
Ly49C, Ly49F, Ly49H and Ly49I are members of the lectin like homodimeric Ly49 family of cell surface receptors. Mouse Ly49 receptors exhibit allelic specificity for MHC class I Ia molecules and are thought to serve to prevent natural killer (NK) cells from attacking normal cells, while allowing them to attack infected or transformed cells in which class I molecules have been down regulated. (Ref.2) These inhibitory receptors are also expressed on a subpopulation of mouse CD8+ T cells.Synonyms: Killer cell lectin-like receptor, Klra3, Klra6, Klra8, Klra9, Ly-49C, Ly-49F, Ly-49H, Ly-49I, Ly49C, Ly49F, Ly49H, Ly49I, T cell surface glycoprotein Ly 49C, T cell surface glycoprotein Ly 49F, T cell surface glycoprotein Ly 49H, T cell surface glycoprotein Ly 49I