Dual Specificity Phosphatase 8 (DUSP8) (AA 250-300) antibody

Details for Product No. ABIN372410, Supplier: Log in to see
Antigen
  • zgc:77593
  • C11orf81
  • HB5
  • HVH-5
  • HVH8
  • 5530400B01Rik
  • AI593498
  • Nttp1
  • Hb5
  • M3/6
  • DUSP8
  • dual specificity phosphatase 8
  • dual specificity phosphatase 8a
  • dual specificity protein phosphatase 8
  • DUSP8
  • dusp8
  • dusp8a
  • DSP8
  • Dusp8
  • LOC615727
Epitope
AA 250-300
16
15
10
5
2
2
1
1
1
1
Reactivity
Human
68
12
8
5
2
1
1
1
1
Host
Rabbit
50
17
1
Clonality
Polyclonal
Conjugate
Un-conjugated
3
3
3
3
3
3
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
62
36
26
10
6
5
2
1
Options
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Immunogen Synthetic peptide corresponding to a portion of amino acids 250-300 of human DUSP8.
Isotype IgG
Specificity This antibody recognizes DUSP8/VH5.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Protein G Chromatography.
Antigen
Background USP8 is a ubiquitin specific protease that plays an important regulatory role at the level of protein turnover by preventing degradation. USP8 is involved in cell proliferation, and probably regulates the stability of STAM2 and RASGRF1. USP8 may regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and STAM2. As revealed by structur/function studies, USP8 forms a ternary complex with RNF128 and OTUB1, and interacts with the SH3 domain of STAM2 and RASGRF1. Expression of USP8 is induced Upon growth stimulation in starved human fibroblasts, and expression decreases in response to growth arrest induced by cell-cell contact.Synonyms: Dual specificity protein phosphatase 8
Molecular Weight 66 kDa.
Gene ID 1850
NCBI Accession NP_004411
UniProt Q13202
Application Notes Immunohistochemistry on Paraffin Sections: 10 μg/mL. Western blot: 1-3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer PBS containing 0.2 % Gelatin as stabilizer and 0.05 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
 image for anti-Dual Specificity Phosphatase 8 (DUSP8) (AA 250-300) antibody (ABIN372410) anti-Dual Specificity Phosphatase 8 (DUSP8) (AA 250-300) antibody
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